This article is part of the Research Topic <i>Leishmania</i>: Early encounters

Review ARTICLE

Front. Cell. Infect. Microbiol., 12 July 2012 | doi: 10.3389/fcimb.2012.00099

Leishmania RNA virus: when the host pays the toll

Mary-Anne Hartley1, Catherine Ronet1, Haroun Zangger1, Stephen M. Beverley2 and Nicolas Fasel1*
  • 1Department of Biochemistry, University of Lausanne, Epalinges, Switzerland
  • 2Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, USA

The presence of an RNA virus in a South American subgenus of the Leishmania parasite, L. (Viannia), was detected several decades ago but its role in leishmanial virulence and metastasis was only recently described. In Leishmania guyanensis, the nucleic acid of Leishmania RNA virus (LRV1) acts as a potent innate immunogen, eliciting a hyper-inflammatory immune response through toll-like receptor 3 (TLR3). The resultant inflammatory cascade has been shown to increase disease severity, parasite persistence, and perhaps even resistance to anti-leishmanial drugs. Curiously, LRVs were found mostly in clinical isolates prone to infectious metastasis in both their human source and experimental animal model, suggesting an association between the viral hyperpathogen and metastatic complications such as mucocutaneous leishmaniasis (MCL). MCL presents as chronic secondary lesions in the mucosa of the mouth and nose, debilitatingly inflamed and notoriously refractory to treatment. Immunologically, this outcome has many of the same hallmarks associated with the reaction to LRV: production of type 1 interferons, bias toward a chronic Th1 inflammatory state and an impaired ability of host cells to eliminate parasites through oxidative stress. More intriguing, is that the risk of developing MCL is found almost exclusively in infections of the L. (Viannia) subtype, further indication that leishmanial metastasis is caused, at least in part, by a parasitic component. LRV present in this subgenus may contribute to the destructive inflammation of metastatic disease either by acting in concert with other intrinsic “metastatic factors” or by independently preying on host TLR3 hypersensitivity. Because LRV amplifies parasite virulence, its presence may provide a unique target for diagnostic and clinical intervention of metastatic leishmaniasis. Taking examples from other members of the Totiviridae virus family, this paper reviews the benefits and costs of endosymbiosis, specifically for the maintenance of LRV infection in Leishmania parasites, which is often at the expense of its human host.

Keywords: Leishmania, Totiviridae, mucocutaneous leishmaniasis, dsRNA virus, toll-like receptor

Citation: Hartley M-A, Ronet C, Zangger H, Beverley SM and Fasel N (2012) Leishmania RNA virus: when the host pays the toll. Front. Cell. Inf. Microbio. 2:99. doi: 10.3389/fcimb.2012.00099

Received: 25 April 2012; Paper pending published: 24 May 2012;
Accepted: 27 June 2012; Published online: 12 July 2012.

Edited by:

Albert Descoteaux, INRS- Institut Armand-Frappier, Canada

Reviewed by:

Dario S. Zamboni, Universidade de São Paulo, Brazil
Martin Olivier, McGill University, Canada

Copyright: © 2012 Hartley, Ronet, Zangger, Beverley and Fasel. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Nicolas Fasel, Department of Biochemistry, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, Switzerland. e-mail: nicolas.fasel@unil.ch

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