Review ARTICLE

Front. Genet., 29 November 2012 | doi: 10.3389/fgene.2012.00270

CRNDE: a long non-coding RNA involved in CanceR, Neurobiology, and DEvelopment

  • CSIRO Animal, Food and Health Sciences, Preventative Health Flagship, Commonwealth Scientific and Industrial Research Organisation, Sydney, NSW, Australia

CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed (non-protein-coding), a long non-coding RNA (lncRNA) gene that expresses multiple splice variants and displays a very tissue-specific pattern of expression. CRNDE was initially identified as a lncRNA whose expression is highly elevated in colorectal cancer, but it is also upregulated in many other solid tumors and in leukemias. Indeed, CRNDE is the most upregulated lncRNA in gliomas and here, as in other cancers, it is associated with a “stemness” signature. CRNDE is expressed in specific regions within the human and mouse brain; the mouse ortholog is high in induced pluripotent stem cells and increases further during neuronal differentiation. We suggest that CRNDE is a multifunctional lncRNA whose different splice forms provide specific functional scaffolds for regulatory complexes, such as the polycomb repressive complex 2 (PRC2) and CoREST chromatin-modifying complexes, which CRNDE helps pilot to target genes.

Keywords: CRNDE, lncRNA, IRX5, cancer, neurogenesis, 4933436C20Rik, multipotency, glioma

Citation: Ellis BC, Molloy PL and Graham LD (2012) CRNDE: a long non-coding RNA involved in CanceR, Neurobiology, and DEvelopment. Front. Gene. 3:270. doi: 10.3389/fgene.2012.00270

Received: 31 August 2012; Paper pending published: 26 September 2012;
Accepted: 07 November 2012; Published online: 29 November 2012.

Edited by:

Peng Jin, Emory University School of Medicine, USA

Reviewed by:

Rory Johnson, Centre for Genomic Regulation, Spain
Fei Li, Nanjing Agricultural University, China

Copyright: © 2012 Ellis, Molloy and Graham. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Lloyd D. Graham, CSIRO Animal, Food and Health Sciences, Commonwealth Scientific and Industrial Research Organisation, P.O. Box 52, North Ryde, Sydney, NSW 1670, Australia. e-mail: lloyd.graham@csiro.au

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