Perspective ARTICLE

Front. Genet., 19 March 2013 | doi: 10.3389/fgene.2013.00031

The two halves of U-shaped mortality

  • 1Max-Planck Odense Center on the Biodemography of Aging, Odense, Denmark
  • 2Institute of Biology, University of Southern Denmark, Odense, Denmark
  • 3Department of Biology, Pomona College, Claremont, CA, USA

Gerontology focuses on deterioration with increasing age, but in most populations most variables, including survival probability, improve at early ages (ontogenescence) before deteriorating at advanced ages (senescence). The extent to which gerontology needs to consider this U-shaped pattern of risk over age depends upon the mechanistic, demographic and evolutionary links and interactions between ontogenescence and senescence. In reading the literature on both senescence and ontogenescence, and in interacting with other biogerontologists, we have encountered a set of what we view as inaccurate or oversimplified claims about ontogenescence, its relationship to senescence and its importance to gerontology. Here, after briefly introducing ontogenescence, we address four of these claims. We demonstrate the counterfactual nature of Claim 1. Ontogenescence is an environmental effect largely absent in protected environments. We then briefly review the literature which leads to Claim 2. Senescence and ontogenescence are parts of the same phenomenon, and describe why we reject this view. We then explain why the rejection of Claim 2 does not necessarily support Claim 3, the idea that senescence and ontogenescence are easily separable. Finally, we examine Claim 4. Gerontologists don’t need to think about ontogenescence, and give some examples of why we consider this misguided.

Keywords: evolutionary demography, life-history, mortality patterns, ontogenescence, senescence

Citation: Levitis DA and Martínez DE (2013) The two halves of U-shaped mortality. Front. Genet. 4:31. doi: 10.3389/fgene.2013.00031

Received: 22 August 2012; Accepted: 25 February 2013;
Published online: 19 March 2013.

Edited by:

Joseph Baur, Perelman School of Medicine at the University of Pennsylvania, USA

Reviewed by:

William R. Swindell, University of Michigan, USA
Charles Mobbs, Mount Sinai School of Medicine, USA

Copyright: © 2013 Levitis and Martínez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Daniel A. Levitis, Max-Planck Odense Center on the Biodemography of Aging, Campusvej 55 5230 Odense, Denmark. e-mail: levitis@biology.sdu.dk

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