As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and function is needed in order to decipher their immune-modulatory roles, notably with the recent highlighting of regulatory B cells. microRNAs (miRNAs), key factors in various biological and pathological processes, have been shown to be essential for B-cell homeostasis, and therefore understanding their participation in B-cell biology could help identify biomarkers and contribute toward curing B-cell-related immune disorders. This review aims to report studies casting light on the roles played by miRNAs in B-cell lineage and function and B-cell-related immune pathologies.
Keywords: B cell, immunology, immune disorder, microRNA, gene-expression regulation
Citation: Danger R, Braza F, Giral M, Soulillou J-P and Brouard S (2014) MicroRNAs, major players in B cells homeostasis and function. Front. Immunol. 5:98. doi: 10.3389/fimmu.2014.00098
Received: 01 October 2013; Accepted: 24 February 2014;
Published online: 11 March 2014.
Edited by:Frans Claas, Leiden University Medical Center, Netherlands
Reviewed by:Philippe Saas, Etablissement Français du Sang BFC, France
Copyright: © 2014 Danger, Braza, Giral, Soulillou and Brouard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Sophie Brouard, Institut National de la Santé et de la Recherche Médicale, U1064, 30 Bd Jean Monnet, 44093 Nantes Cedex 93, France e-mail: email@example.com