Original Research ARTICLE

Front. Aging Neurosci., 05 December 2012 | doi: 10.3389/fnagi.2012.00034

Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory

Onder Albayram*, Andras Bilkei-Gorzo and Andreas Zimmer
  • Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany

Previous studies have shown that cannabinoid 1 (CB1) receptor signaling dissociates between reward-associated and aversive memories. The influence of CB1 receptors on the aversion-driven spatial learning in the Morris water maze test is strongly age-dependent: mice with genetic deletion of CB1 receptors (Cnr1−/−) show superior learning when young but inferior learning when old compared to age-matched wild-type mice. Whether the reward-driven spatial learning is influenced in the same way by CB1 receptor signaling as the aversion-driven learning remains unclear. Thus, we examined the performance of Cn1−/− and their wild-type littermates at ages of 2-, 5-, and 12-months-old in the eight-arm radial maze test—a reward-motivated model of spatial learning. Interestingly, 2-months-old Cnr1−/− mice had a superior learning ability to wild-type mice. At the age of 5-months, Cnr1−/− mice showed the same performance as the wild-type littermates. However, 12-months-old Cnr1−/− mice showed significantly impaired performances in each parameter of the test. Accordingly, this study provides compelling support for our previous result that genetic deletion of CB1 receptor leads to early onset of age-related memory decline, similarly affecting both reward and aversion-driven learning.

Keywords: cannabinoid receptor, aging, emotional valence, motivation, spatial learning, mice

Citation: Albayram O, Bilkei-Gorzo A and Zimmer A (2012) Loss of CB1 receptors leads to differential age-related changes in reward-driven learning and memory. Front. Ag. Neurosci. 4:34. doi: 10.3389/fnagi.2012.00034

Received: 23 August 2012; Paper pending published: 20 September 2012;
Accepted: 19 November 2012; Published online: 05 December 2012.

Edited by:

Gizem Donmez, Tufts University School of Medicine, USA

Reviewed by:

Junming Wang, University of Mississippi Medical Center, USA
Ashok Kumar, University of Florida, USA

Copyright © 2012 Albayram, Bilkei-Gorzo and Zimmer. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Onder Albayram, Institute of Molecular Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53127 Bonn, Germany. e-mail: oalbayram@gmail.com

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