Front. Neurol., 02 June 2014 | doi: 10.3389/fneur.2014.00084

Mechanisms of body weight fluctuations in Parkinson’s disease

  • 1Movement Disorder Unit, Department of Psychiatry and Neurology, University Hospital Grenoble, Grenoble, France
  • 2Unité 836, Équipe 11, INSERM, Grenoble Institut des Neurosciences, Grenoble, France
  • 3Joseph Fourier University, Grenoble, France

Typical body weight changes are known to occur in Parkinson’s disease (PD). Weight loss has been reported in early stages as well as in advanced disease and malnutrition may worsen the clinical state of the patient. On the other hand, an increasing number of patients show weight gain under dopamine replacement therapy or after surgery. These weight changes are multifactorial and involve changes in energy expenditure, perturbation of homeostatic control, and eating behavior modulated by dopaminergic treatment. Comprehension of the different mechanisms contributing to body weight is a prerequisite for the management of body weight and nutritional state of an individual PD patient. This review summarizes the present knowledge and highlights the necessity of evaluation of body weight and related factors, as eating behavior, energy intake, and expenditure in PD.

Keywords: Parkinson’s disease, body weight, eating behavior, DBS, dopamine, binge-eating disorder

Citation: Kistner A, Lhommée E and Krack P (2014) Mechanisms of body weight fluctuations in Parkinson’s disease. Front. Neurol. 5:84. doi: 10.3389/fneur.2014.00084

Received: 03 January 2014; Paper pending published: 10 April 2014;
Accepted: 16 May 2014; Published online: 02 June 2014.

Edited by:

Ryuji Kaji, Tokushima University Hospital, Japan

Reviewed by:

Maria Fiorella Contarino, Academic Medical Center, Netherlands
Satoshi Goto, Tokushima University Hospital, Japan

Copyright: © 2014 Kistner, Lhommée and Krack. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Andrea Kistner, Department of Neurology, University Hospital Grenoble, BP 217, 38043 Grenoble Cedex 09, France e-mail:

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