Review ARTICLE

Front. Physiol., 12 December 2012 | doi: 10.3389/fphys.2012.00468

Modulation of myocardial contraction by peroxynitrite

  • 1Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA
  • 2Division of Cardiovascular Pathology, Department of Pathology, Johns Hopkins University, Baltimore, MD, USA
  • 3Department of Internal Medicine: Division of Cardiovascular Medicine, Davis Heart and Lung Research Institute, The Ohio State University, Columbus, OH, USA

Peroxynitrite is a potent oxidant that is quickly emerging as a crucial modulator of myocardial function. This review will focus on the regulation of myocardial contraction by peroxynitrite during health and disease, with a specific emphasis on cardiomyocyte Ca2+ handling, proposed signaling pathways, and protein end-targets.

Keywords: myocyte, peroxynitrite, nitric oxide synthase, Ca2+, cAMP-dependent protein kinase, protein phosphatase 2a

Citation: Kohr MJ, Roof SR, Zweier JL and Ziolo MT (2012) Modulation of myocardial contraction by peroxynitrite. Front. Physio. 3:468. doi: 10.3389/fphys.2012.00468

Received: 08 October 2012; Paper pending published: 31 October 2012;
Accepted: 26 November 2012; Published online: 12 December 2012.

Edited by:

Lars S. Maier, Georg-August-Universität, Germany

Reviewed by:

Jens Kockskämper, Philipps-University Marburg, Germany
Christoph Maack, Universitätsklinikum des Saarlandes, Germany

Copyright © 2012 Kohr, Roof, Zweier and Ziolo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Mark T. Ziolo, Department of Physiology and Cell Biology, Davis Heart and Lung Research Institute, The Ohio State University, 304 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA. e-mail: ziolo.1@osu.edu

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