2.6
Impact Factor
This article is part of the Research Topic Leishmania: Early encounters

Review ARTICLE

Front. Cell. Infect. Microbiol., 04 May 2012 | http://dx.doi.org/10.3389/fcimb.2012.00059

The influence of early neutrophil-Leishmania interactions on the host immune response to infection

  • Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

Neutrophils are the first cells recruited to the dermal site of Leishmania infection following injection by needle or sand fly bite. The role of neutrophils in either promoting or suppressing host immunity remains controversial. We discuss the events driving neutrophil recruitment, their interaction with the parasite and apoptotic fate, and the nature of their encounters with other innate cells. We suggest that the influence of the neutrophil response on infection outcome critically depends on the timing of their recruitment and the tissue environment in which it occurs.

Keywords: neutrophils, Leishmania, inflammation, immune response, sand fly, apoptosis, dendritic cells, macrophages

Citation: Ribeiro-Gomes FL and Sacks D (2012) The influence of early neutrophil-Leishmania interactions on the host immune response to infection. Front. Cell. Inf. Microbio. 2:59. doi: 10.3389/fcimb.2012.00059

Received: 16 February 2012; Paper pending published: 18 March 2012;
Accepted: 16 April 2012; Published online: 04 May 2012.

Edited by:

Stephen M. Beverley, Washington University in St. Louis, USA

Reviewed by:

Jordi Torrelles, Ohio State University, USA
Michael L. Vasil, University of Colorado Medical School, USA

Copyright: © 2012 Ribeiro-Gomes and Sacks. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: David Sacks, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Dr. MSC 0425, Bethesda, MD 20892-0425, USA. e-mail: dsacks@nih.gov