Vaccination is the most important approach to counteract infectious diseases. Thus, the development of new and improved vaccines for existing, emerging, and re-emerging diseases is an area of great interest to the scientific community and general public. Traditional approaches to subunit antigen discovery and vaccine development lack consideration for the critical aspects of public safety and activation of relevant protective host immunity. The availability of genomic sequences for pathogenic Brucella spp. and their hosts have led to development of systems-wide analytical tools that have provided a better understanding of host and pathogen physiology while also beginning to unravel the intricacies at the host-pathogen interface. Advances in pathogen biology, host immunology, and host-agent interactions have the potential to serve as a platform for the design and implementation of better-targeted antigen discovery approaches. With emphasis on Brucella spp., we probe the biological aspects of host and pathogen that merit consideration in the targeted design of subunit antigen discovery and vaccine development.
Keywords: intracellular pathogens, vaccines, subunit vaccine, antigen discovery, Brucellosis, reverse vaccinology
Citation: Gomez G, Adams LG, Rice-Ficht A and Ficht TA (2013) Host-Brucella interactions and the Brucella genome as tools for subunit antigen discovery and immunization against brucellosis. Front. Cell. Infect. Microbiol. 3:17. doi: 10.3389/fcimb.2013.00017
Received: 16 October 2012; Accepted: 26 April 2013;
Published online: 16 May 2013.
Edited by:Lisa A. Morici, Tulane University School of Medicine, USA
Reviewed by:John Boyce, Monash University, Australia
Copyright © 2013 Gomez, Adams, Rice-Ficht and Ficht. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Gabriel Gomez, Department of Veterinary Pathobiology, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, 113 Veterinary Medical Research (VMR) Building, College Station, TX 77843, USA. e-mail: email@example.com