@ARTICLE{10.3389/fcvm.2017.00039, AUTHOR={Herm, Juliane and Hoppe, Berthold and Siegerink, Bob and Nolte, Christian H. and Koscielny, Jürgen and Haeusler, Karl Georg}, TITLE={A Prothrombotic Score Based on Genetic Polymorphisms of the Hemostatic System Differs in Patients with Ischemic Stroke, Myocardial Infarction, or Peripheral Arterial Occlusive Disease}, JOURNAL={Frontiers in Cardiovascular Medicine}, VOLUME={4}, YEAR={2017}, URL={https://www.frontiersin.org/articles/10.3389/fcvm.2017.00039}, DOI={10.3389/fcvm.2017.00039}, ISSN={2297-055X}, ABSTRACT={BackgroundWhile twin studies indicate a genetic component in arterial thrombosis such as ischemic stroke, myocardial infarction (MI), or peripheral arterial occlusive disease (PAOD), the clinical relevance of hemostatic polymorphisms in arterial thrombosis is a matter of debate.MethodsWe analyzed the prevalence of 13 hemostatic polymorphisms [PAI-1, PLAT, F5 (including factor V Leiden and HR2 haplotype), F2, F7, F13A, FGB, TFPI, THBD, MTHFR, ACE, and ITGA2] in patients referred to a tertiary referral center. A “prothrombotic score” was calculated by dividing the number of risk-increasing polymorphisms for thrombosis minus the number of risk-lowering polymorphisms (F7 and F13A) by the number of polymorphisms tested.ResultsDatasets of 144 patients with prior ischemic stroke (mean age 44 ± 13 years; 65% female) were compared to 62 patients with MI or PAOD (mean age 54 ± 14 years; 47% female). The prothrombotic score was lower in MI and PAOD patients compared to stroke patients [odds ratios 2.7 (95% confidence intervals 1.1–6.2)]. Frequencies of individual polymorphisms did not differ between both groups.ConclusionPatients with MI or PAOD had a lower burden of prothrombotic mutations compared to patients with prior stroke, indicating that a prothrombotic state might play a different role in distinct forms of arterial thrombosis.} }