Mini Review ARTICLE

Front. Endocrinol., 27 June 2012 | http://dx.doi.org/10.3389/fendo.2012.00078

Parathyroid diseases and animal models

Yasuo Imanishi*, Yuki Nagata and Masaaki Inaba
  • Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan

Circulating calcium and phosphate are tightly regulated by three hormones: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). PTH acts to stimulate a rapid increment in serum calcium and has a crucial role in calcium homeostasis. Major target organs of PTH are kidney and bone. The oversecretion of the hormone results in hypercalcemia, caused by increased intestinal calcium absorption, reduced renal calcium clearance, and mobilization of calcium from bone in primary hyperparathyroidism. In chronic kidney disease, secondary hyperparathyroidism of uremia is observed in its early stages, and this finally develops into the autonomous secretion of PTH during maintenance hemodialysis. Receptors in parathyroid cells, such as the calcium-sensing receptor, vitamin D receptor, and FGF receptor (FGFR)-Klotho complex have crucial roles in the regulation of PTH secretion. Genes such as Cyclin D1, RET, MEN1, HRPT2, and CDKN1B have been identified in parathyroid diseases. Genetically engineered animals with these receptors and the associated genes have provided us with valuable information on the patho-physiology of parathyroid diseases. The application of these animal models is significant for the development of new therapies.

Keywords: calcitriol, CaR, cinacalcet, CKD, FGF-23, hyperparathyroidism, Klotho, PTH

Citation: Imanishi Y, Nagata Y and Inaba M (2012) Parathyroid diseases and animal models. Front. Endocrin. 3:78. doi: 10.3389/fendo.2012.00078

Received: 21 April 2012; Accepted: 31 May 2012;
Published online: 27 June 2012.

Edited by:

Francesca Carlomagno, Universita’ degli Studi di Napoli Federico II, Italy

Reviewed by:

Caroline Kim, Perelman School of Medicine at the University of Pennsylvania, USA
Nikolaos Stathatos, Massachusetts General Hospital, USA

Copyright: © 2012 Imanishi, Nagata and Inaba. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Yasuo Imanishi, Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. e-mail: imanishi@med.osaka-cu.ac.jp