This article is part of the Research Topic Biological Ontologies and Semantic Biology

Original Research ARTICLE

Front. Genet., 23 May 2012 | http://dx.doi.org/10.3389/fgene.2012.00079

IMGT-ONTOLOGY 2012

  • IMGT®, the international ImMunoGenetics information system®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine, UPR CNRS, Montpellier, France

Immunogenetics is the science that studies the genetics of the immune system and immune responses. Owing to the complexity and diversity of the immune repertoire, immunogenetics represents one of the greatest challenges for data interpretation: a large biological expertise, a considerable effort of standardization and the elaboration of an efficient system for the management of the related knowledge were required. IMGT®, the international ImMunoGeneTics information system® (http://www.imgt.org) has reached that goal through the building of a unique ontology, IMGT-ONTOLOGY, which represents the first ontology for the formal representation of knowledge in immunogenetics and immunoinformatics. IMGT-ONTOLOGY manages the immunogenetics knowledge through diverse facets that rely on the seven axioms of the Formal IMGT-ONTOLOGY or IMGT-Kaleidoscope: “IDENTIFICATION,” “DESCRIPTION,” “CLASSIFICATION,” “NUMEROTATION,” “LOCALIZATION,” “ORIENTATION,” and “OBTENTION.” The concepts of identification, description, classification, and numerotation generated from the axioms led to the elaboration of the IMGT® standards that constitute the IMGT Scientific chart: IMGT® standardized keywords (concepts of identification), IMGT® standardized labels (concepts of description), IMGT® standardized gene and allele nomenclature (concepts of classification) and IMGT unique numbering and IMGT Collier de Perles (concepts of numerotation). IMGT-ONTOLOGY has become the global reference in immunogenetics and immunoinformatics for the knowledge representation of immunoglobulins (IG) or antibodies, T cell receptors (TR), and major histocompatibility (MH) proteins of humans and other vertebrates, proteins of the immunoglobulin superfamily (IgSF) and MH superfamily (MhSF), related proteins of the immune system (RPI) of vertebrates and invertebrates, therapeutic monoclonal antibodies (mAbs), fusion proteins for immune applications (FPIA), and composite proteins for clinical applications (CPCA).

Keywords: IMGT, immunogenetics, immunoinformatics, IMGT-ONTOLOGY, immunoglobulin, antibody, T cell receptor, immune repertoire

Citation: Giudicelli V and Lefranc M-P (2012) IMGT-ONTOLOGY 2012. Front. Gene. 3:79. doi: 10.3389/fgene.2012.00079

Received: 10 February 2012; Accepted: 24 April 2012;
Published online: 23 May 2012.

Edited by:

John Hancock, Medical Research Council, UK

Reviewed by:

Ruth Lovering, University College London, UK
Anna Maria Masci, Duke University, USA

Copyright: © 2012 Giudicelli and Lefranc. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Marie-Paule Lefranc, IMGT®, the international ImMunoGenetics information system®, Université Montpellier 2, Laboratoire d’ImmunoGénétique Moléculaire, Institut de Génétique Humaine, UPR CNRS 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 5, France. e-mail: Marie-Paule.Lefranc@igh.cnrs.fr