Mast cells and company
- 1 Institut Pasteur, Département d’Immunologie, Unité d’Allergologie Moléculaire et Cellulaire, Paris, France
- 2 Inserm, Unité 760, Paris, France
Classically, allergy depends on IgE antibodies and on high-affinity IgE receptors expressed by mast cells and basophils. This long accepted IgE/FcεRI/mast cell paradigm, on which the definition of immediate hypersensitivity was based in the Gell and Coomb’s classification, appears too reductionist. Recently accumulated evidence indeed requires that not only IgE but also IgG antibodies, that not only FcεRI but also FcγR of the different types, that not only mast cells and basophils but also neutrophils, monocytes, macrophages, eosinophils, and other myeloid cells be considered as important players in allergy. This view markedly changes our understanding of allergic diseases and, possibly, their treatment.
Keywords: mast cells, basophils, neutrophils, Fc receptors, antibodies, anaphylaxis, allergy
Citation: Jönsson F and Daëron M (2012) Mast cells and company. Front. Immun. 3:16. doi: 10.3389/fimmu.2012.00016
Received: 12 December 2011; Accepted: 01 February 2012;
Published online: 20 February 2012.
Edited by:Toshiaki Kawakami, La Jolla Institute for Allergy and Immunology, USA
Reviewed by:Francesca Levi-Schaffer, The Hebrew University of Jerusalem, Israel
Yoshimichi Okayama, Nihon University School of Medicine, Japan
Copyright: © 2012 Jönsson and Daëron. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
*Correspondence: Marc Daëron, Unité d’Allergologie Moléculaire et Cellulaire, Département d’Immunologie, Institut Pasteur, Bâtiment Metchnikoff, 25 rue du Docteur Roux, 75015 Paris, France. e-mail: firstname.lastname@example.org