Perspective ARTICLE

Front. Immunol., 12 July 2012 | http://dx.doi.org/10.3389/fimmu.2012.00200

Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer

  • Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, Moriguchi, Osaka, Japan

The architecture of secondary lymphoid organs (SLOs) is supported by several non-hematopoietic stromal cells. Currently it is established that two distinct stromal subsets, follicular dendritic cells and fibroblastic reticular cells, play crucial roles in the formation of tissue compartments within SLOs, i.e., the follicle and T zone, respectively. Although stromal cells in the anlagen are essential for SLO development, the relationship between these primordial cells and the subsets in adulthood remains poorly understood. In addition, the roles of stromal cells in the entry of antigens into the compartments through some tissue structures peculiar to SLOs remain unclear. A recently identified stromal subset, marginal reticular cells (MRCs), covers the margin of SLOs that are primarily located in the outer edge of follicles and construct a unique reticulum. MRCs are closely associated with specialized endothelial or epithelial structures for antigen transport. The similarities in marker expression profiles and successive localization during development suggest that MRCs directly descend from organizer stromal cells in the anlagen. Therefore, MRCs are thought to be a crucial stromal component for the organization and function of SLOs.

Keywords: CXCL13, fibroblastic reticular cell, follicular dendritic cell, lymph node, marginal reticular cell, organizer, secondary lymphoid organ, stromal cell

Citation: Katakai T (2012) Marginal reticular cells: a stromal subset directly descended from the lymphoid tissue organizer. Front. Immun. 3:200. doi:10.3389/fimmu.2012.00200

Received: 01 June 2012; Accepted: 28 June 2012;
Published online: 12 July 2012

Edited by:

Christopher G. Mueller, Centre National de la Recherche Scientifique, France

Reviewed by:

Scott Mueller, The University of Melbourne, Australia
Tom Cupedo, Erasmus University Medical Center, Netherlands

Copyright: © 2012 Katakai. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Tomoya Katakai, Department of Molecular Genetics, Institute of Biomedical Science, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan. e-mail: katakait@takii.kmu.ac.jp

Abbreviations:DC, dendritic cell; FAE, follicle-associated epithelium; FDC, follicular dendritic cell; FRC, fibroblastic reticular cell; HEV, high endothelial venue; IFC, interfollicular channel; IFR, interfollicular region; LN, lymph node; LT, lymphotoxin; LTi, lymphoid tissue inducer; LTo, lymphoid tissue organizer; MALT,mucosal associated lymphoid tissue; MRC, marginal reticular cell; MS, marginal sinus; MZ, marginal zone; PALS, periarteriolar lymphoid sheath; PP, Peyer’s patch; SED, subepithelial dome; SLO, secondary lymphoid organ; SCS, subcapsular sinus; TLT, tertiary lymphoid tissue.