Review ARTICLE

Front. Immunol., 14 August 2012 | http://dx.doi.org/10.3389/fimmu.2012.00250

Controlling the HIV/AIDS epidemic: current status and global challenges

  • Vaccine Branch, Section on Immune Biology of Retroviral Infection, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

This review provides an overview of the current status of the global HIV pandemic and strategies to bring it under control. It updates numerous preventive approaches including behavioral interventions, male circumcision (MC), pre- and post-exposure prophylaxis (PREP and PEP), vaccines, and microbicides. The manuscript summarizes current anti-retroviral treatment options, their impact in the western world, and difficulties faced by emerging and resource-limited nations in providing and maintaining appropriate treatment regimens. Current clinical and pre-clinical approaches toward a cure for HIV are described, including new drug compounds that target viral reservoirs and gene therapy approaches aimed at altering susceptibility to HIV infection. Recent progress in vaccine development is summarized, including novel approaches and new discoveries.

Keywords: animal model, ART treatment, global strategies, HIV pandemic, prevention, vaccine development

Citation: Demberg T and Robert-Guroff M (2012) Controlling the HIV/AIDS epidemic: current status and global challenges. Front. Immun. 3:250. doi: 10.3389/fimmu.2012.00250

Received: 18 May 2012; Accepted: 27 July 2012;
Published online: 14 August 2012.

Edited by:

Marc H. V. Van Regenmortel, University of Strasbourg, France

Reviewed by:

Marc H. V. Van Regenmortel, University of Strasbourg, France
Marc P. Girard, University Paris-Diderot, France
Catarina E. Hioe, New York University School of Medicine, USA

Copyright © 2012 Demberg and Robert-Guroff. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Thorsten Demberg, Vaccine Branch, National Cancer Institute, National Institutes of Health, 41 Medlars Drive, Building 41, Room D804, Bethesda, MD 20892-5065, USA. e-mail: dembergt@mail.nih.gov