The history of vaccination clearly demonstrates that vaccines have been highly successful in preventing infectious diseases, reducing significantly the incidence of childhood diseases and mortality. However, many infections are still not preventable with the currently available vaccines and they represent a major cause of mortality worldwide. In the twenty-first century, the innovation brought by novel technologies in antigen discovery and formulation together with a deeper knowledge of the human immune responses are paving the way for the development of new vaccines. Final goal will be to rationally design effective vaccines where conventional approaches have failed.
Keywords: vaccination, glyco-conjugate, technologies, vaccine design, structural vaccinology
Citation: Finco O and Rappuoli R (2014) Designing vaccines for the twenty-first century society. Front. Immunol. 5:12. doi: 10.3389/fimmu.2014.00012
Received: 24 November 2013; Paper pending published: 16 December 2013;
Accepted: 08 January 2014; Published online: 23 January 2014.
Edited by:Kendall A. Smith, Cornell University, USA
Reviewed by:António G. Castro, University of Minho, Portugal
Copyright: © 2014 Finco and Rappuoli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Rino Rappuoli, Research Center, Novartis Vaccines and Diagnostics, Via Fiorentina 1, Siena 53100, Italy e-mail: firstname.lastname@example.org