This article is part of the Research Topic A new focus on B cells in solid organ transplantation


Front. Immunol., 11 March 2014 | doi: 10.3389/fimmu.2014.00098

MicroRNAs, major players in B cells homeostasis and function

imageRichard Danger1,2,3, imageFaouzi Braza2,3, imageMagali Giral2,3,4, imageJean-Paul Soulillou2,3,4 and imageSophie Brouard2,3,4*
  • 1Institute of Liver Studies, Medical Research Council Centre for Transplantation, King’s College Hospital, King’s College London, London, UK
  • 2Institut National de la Santé et de la Recherche Médicale, U1064, Institut de Transplantation Urologie Néphrologie, Nantes, France
  • 3Faculté de Médecine, Université de Nantes, Nantes, France
  • 4Centre Hospitalier Universitaire, Hôtel Dieu, Nantes, France

As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and function is needed in order to decipher their immune-modulatory roles, notably with the recent highlighting of regulatory B cells. microRNAs (miRNAs), key factors in various biological and pathological processes, have been shown to be essential for B-cell homeostasis, and therefore understanding their participation in B-cell biology could help identify biomarkers and contribute toward curing B-cell-related immune disorders. This review aims to report studies casting light on the roles played by miRNAs in B-cell lineage and function and B-cell-related immune pathologies.

Keywords: B cell, immunology, immune disorder, microRNA, gene-expression regulation

Citation: Danger R, Braza F, Giral M, Soulillou J-P and Brouard S (2014) MicroRNAs, major players in B cells homeostasis and function. Front. Immunol. 5:98. doi: 10.3389/fimmu.2014.00098

Received: 01 October 2013; Accepted: 24 February 2014;
Published online: 11 March 2014.

Edited by:

Frans Claas, Leiden University Medical Center, Netherlands

Reviewed by:

Philippe Saas, Etablissement Français du Sang BFC, France
Michael Eikmans, Leiden University Medical Center, Netherlands

Copyright: © 2014 Danger, Braza, Giral, Soulillou and Brouard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Sophie Brouard, Institut National de la Santé et de la Recherche Médicale, U1064, 30 Bd Jean Monnet, 44093 Nantes Cedex 93, France e-mail:

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