This article is part of the Research Topic Immune Interactions during the Reproductive Cycle


Front. Immunol., 19 May 2014 | doi: 10.3389/fimmu.2014.00205

The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy

  • 1Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de Los Andes, Santiago, Chile
  • 2Cells for Cells, Santiago, Chile
  • 3REGENERO, Consortium in Tissue Engineering, Santiago, Chile

Menstrual-derived stem cells (MenSCs) are a new source of mesenchymal stem cells isolated from the menstrual fluid. Currently, there is a growing interest in their clinical potential due to fact that they are multipotent, highly proliferative, and easy to obtain in a non-invasive manner. Sampling can be repeated periodically in a simplified and reproducible manner devoid of complications that no existing cell source can match. MenSCs are also free of ethical dilemmas, and display novel properties with regard to presently known adult derived stem cells. This review details their distinctive biological properties regarding immunophenotype and function, proliferation rate, differentiation potential, and paracrine effects mediated by secreted factors. Their possible role in antenatal diagnosis is also discussed. While more insight on their immunomodulatory and diagnostic properties is needed, the impact of clinical and epidemiological factors, such as age, use of contraceptives, or hormonal status still requires further investigations to properly assess their current and future use in clinical application and diagnosis.

Keywords: menstrual stem cells, stem cells, menstrual blood, cell therapy, mesenchymal stem cells

Citation: Khoury M, Alcayaga-Miranda F, Illanes SE and Figueroa FE (2014) The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy. Front. Immunol. 5:205. doi: 10.3389/fimmu.2014.00205

Received: 28 February 2014; Accepted: 25 April 2014;
Published online: 19 May 2014.

Edited by:

Sinuhe Hahn, University Clinics Basel, Switzerland

Reviewed by:

Michael Kracht, Justus-Liebig-University Giessen, Germany
Sinuhe Hahn, University Clinics Basel, Switzerland

Copyright: © 2014 Khoury, Alcayaga-Miranda, Illanes and Figueroa. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Maroun Khoury, Centro de investigacion biomedical (CIB), Universidad de Los Andes, San Carlos de Apoquindo 2200, Las Condes, Santiago, Chile e-mail:

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