@ARTICLE{10.3389/fimmu.2014.00244, AUTHOR={Perez-Sepulveda, Alejandra and Torres, Maria Jose and Khoury, Maroun and Illanes, Sebastian E.}, TITLE={Innate Immune System and Preeclampsia}, JOURNAL={Frontiers in Immunology}, VOLUME={5}, YEAR={2014}, URL={https://www.frontiersin.org/articles/10.3389/fimmu.2014.00244}, DOI={10.3389/fimmu.2014.00244}, ISSN={1664-3224}, ABSTRACT={Normal pregnancy is considered as a Th2 type immunological state that favors an immune-tolerance environment in order to prevent fetal rejection. Preeclampsia (PE) has been classically described as a Th1/Th2 imbalance; however, the Th1/Th2 paradigm has proven insufficient to fully explain the functional and molecular changes observed during normal/pathological pregnancies. Recent studies have expanded the Th1/Th2 into a Th1/Th2/Th17 and regulatory T-cells paradigm and where dendritic cells could have a crucial role. Recently, some evidence has emerged supporting the idea that mesenchymal stem cells might be part of the feto-maternal tolerance environment. This review will discuss the involvement of the innate immune system in the establishment of a physiological environment that favors pregnancy and possible alterations related to the development of PE.} }