@ARTICLE{10.3389/fimmu.2015.00640, AUTHOR={Wakkach, Abdelilah and Rouleau, Matthieu and Blin-Wakkach, Claudine}, TITLE={Osteoimmune Interactions in Inflammatory Bowel Disease: Central Role of Bone Marrow Th17 TNFα Cells in Osteoclastogenesis}, JOURNAL={Frontiers in Immunology}, VOLUME={6}, YEAR={2015}, URL={https://www.frontiersin.org/articles/10.3389/fimmu.2015.00640}, DOI={10.3389/fimmu.2015.00640}, ISSN={1664-3224}, ABSTRACT={Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4+ T cells are central players in this crosstalk. There is an emerging understanding that CD4+ T cells play an important role in the bone marrow (BM) under physiological and pathological conditions and modulate the differentiation of bone-resorbing osteoclasts. However, identification of the mechanisms that maintain CD4+ T cells in the BM is still a matter of investigation. This article describes the CD4+ T cell populations of the BM and reviews their role as osteoclastogenic population in inflammatory bowel disease.} }