%A Wakkach,Abdelilah %A Rouleau,Matthieu %A Blin-Wakkach,Claudine %D 2015 %J Frontiers in Immunology %C %F %G English %K Th17 Cells,Osteoclasts,Bone Marrow,Inflammatory Bowel Diseases,Osteoporosis,osteoimmunology %Q %R 10.3389/fimmu.2015.00640 %W %L %M %P %7 %8 2015-December-18 %9 Mini Review %+ Abdelilah Wakkach,CNRS, UMR 7370, Laboratoire de PhysioMédecine Moléculaire (LP2M), Faculté de Médecine,France,wakkach@unice.fr %+ Abdelilah Wakkach,University Nice Sophia Antipolis,France,wakkach@unice.fr %# %! bone marrow memory CD+ T cells in IBD associated with osteoporosis %* %< %T Osteoimmune Interactions in Inflammatory Bowel Disease: Central Role of Bone Marrow Th17 TNFα Cells in Osteoclastogenesis %U https://www.frontiersin.org/articles/10.3389/fimmu.2015.00640 %V 6 %0 JOURNAL ARTICLE %@ 1664-3224 %X Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4+ T cells are central players in this crosstalk. There is an emerging understanding that CD4+ T cells play an important role in the bone marrow (BM) under physiological and pathological conditions and modulate the differentiation of bone-resorbing osteoclasts. However, identification of the mechanisms that maintain CD4+ T cells in the BM is still a matter of investigation. This article describes the CD4+ T cell populations of the BM and reviews their role as osteoclastogenic population in inflammatory bowel disease.