%A Wakkach,Abdelilah
%A Rouleau,Matthieu
%A Blin-Wakkach,Claudine
%D 2015
%J Frontiers in Immunology
%C
%F
%G English
%K Th17 Cells,Osteoclasts,Bone Marrow,Inflammatory Bowel Diseases,Osteoporosis,osteoimmunology
%Q
%R 10.3389/fimmu.2015.00640
%W
%L
%M
%P
%7
%8 2015-December-18
%9 Mini Review
%+ Abdelilah Wakkach,CNRS, UMR 7370, Laboratoire de PhysioMédecine Moléculaire (LP2M), Faculté de Médecine,France,wakkach@unice.fr
%+ Abdelilah Wakkach,University Nice Sophia Antipolis,France,wakkach@unice.fr
%#
%! bone marrow memory CD+ T cells in IBD associated with osteoporosis
%*
%<
%T Osteoimmune Interactions in Inflammatory Bowel Disease: Central Role of Bone Marrow Th17 TNFα Cells in Osteoclastogenesis
%U https://www.frontiersin.org/articles/10.3389/fimmu.2015.00640
%V 6
%0 JOURNAL ARTICLE
%@ 1664-3224
%X Osteoimmunology is an interdisciplinary research field dedicated to the study of the crosstalk between the immune and bone systems. CD4+ T cells are central players in this crosstalk. There is an emerging understanding that CD4+ T cells play an important role in the bone marrow (BM) under physiological and pathological conditions and modulate the differentiation of bone-resorbing osteoclasts. However, identification of the mechanisms that maintain CD4+ T cells in the BM is still a matter of investigation. This article describes the CD4+ T cell populations of the BM and reviews their role as osteoclastogenic population in inflammatory bowel disease.