%A Lawrenz,Matthew %D 2010 %J Frontiers in Microbiology %C %F %G English %K Animal Models,Plague pathogensis,plague vaccines,Yersinia pestis %Q %R 10.3389/fmicb.2010.00119 %W %L %M %P %7 %8 2010-November-04 %9 Review %+ Dr Matthew Lawrenz,University of Louisville School of Medicine,Microbiology and Immunology,CTRB, Rm 618,505 S. Hancock Street,Louisville,40202,KY,United States,matt.lawrenz@louisville.edu %# %! Models to study Yersinia pestis %* %< %T Model Systems to Study Plague Pathogenesis and Develop New Therapeutics %U https://www.frontiersin.org/articles/10.3389/fmicb.2010.00119 %V 1 %0 JOURNAL ARTICLE %@ 1664-302X %X The Gram negative bacterium Yersinia pestis can infect humans by multiple routes to cause plague. Three plague pandemics have occurred and Y. pestis has been linked to biowarfare in the past. The continued risk of plague as a bioweapon has prompted increased research to understand Y. pestis pathogenesis and develop new plague therapeutics. Several in vivo models have been developed for this research and are reviewed here.