Salmonella interaction with and passage through the intestinal mucosa: through the lens of the organism
- Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, MA, USA
Salmonella enterica serotypes are invasive enteric pathogens spread through fecal contamination of food and water sources, and represent a constant public health threat around the world. The symptoms associated with salmonellosis and typhoid disease are largely due to the host response to invading Salmonella, and to the mechanisms these bacteria employ to survive in the presence of, and invade through the intestinal mucosal epithelia. Surmounting this barrier is required for survival within the host, as well as for further dissemination throughout the body, and subsequent systemic disease. In this review, we highlight some of the major hurdles Salmonella must overcome upon encountering the intestinal mucosal epithelial barrier, and examine how these bacteria surmount and exploit host defense mechanisms.
Keywords: Salmonella, intestinal mucosa, tight junctions
Citation: Hallstrom K and McCormick BA (2011) Salmonella interaction with and passage through the intestinal mucosa: through the lens of the organism. Front. Microbio. 2:88. doi: 10.3389/fmicb.2011.00088
Received: 01 February 2011;
Accepted: 13 April 2011;
Published online: 29 April 2011.
Edited by:John S. Gunn, The Ohio State University, USA
Copyright: © 2011 Hallstrom and McCormick. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
*Correspondence: Beth A. McCormick, Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA.e-mail: email@example.com