%A Cassani,Raymundo %A Falk,Tiago %A Fraga,Francisco %A Kanda,Paulo %A Anghinah,Renato %D 2014 %J Frontiers in Aging Neuroscience %C %F %G English %K Alzheimer's disease,automatic diagnosis,Electroencephalogram,amplitude modulation,EEG artifacts,SVM %Q %R 10.3389/fnagi.2014.00055 %W %L %M %P %7 %8 2014-March-25 %9 Original Research %+ Dr Tiago Falk,Institut National de la Recherche Scientifique,Énergie Matériaux Télécommunications,800, Rue de la Gauchetire Ouest, Suite 6900,Montreal,H5A-1K6,Quebec,Canada,Tiago.Falk@inrs.ca %# %! The effects of automated artifact removal algorithms on EEG-based Alzheimer’s disease diagnosis %* %< %T The effects of automated artifact removal algorithms on electroencephalography-based Alzheimer's disease diagnosis %U https://www.frontiersin.org/articles/10.3389/fnagi.2014.00055 %V 6 %0 JOURNAL ARTICLE %@ 1663-4365 %X Over the last decade, electroencephalography (EEG) has emerged as a reliable tool for the diagnosis of cortical disorders such as Alzheimer's disease (AD). EEG signals, however, are susceptible to several artifacts, such as ocular, muscular, movement, and environmental. To overcome this limitation, existing diagnostic systems commonly depend on experienced clinicians to manually select artifact-free epochs from the collected multi-channel EEG data. Manual selection, however, is a tedious and time-consuming process, rendering the diagnostic system “semi-automated.” Notwithstanding, a number of EEG artifact removal algorithms have been proposed in the literature. The (dis)advantages of using such algorithms in automated AD diagnostic systems, however, have not been documented; this paper aims to fill this gap. Here, we investigate the effects of three state-of-the-art automated artifact removal (AAR) algorithms (both alone and in combination with each other) on AD diagnostic systems based on four different classes of EEG features, namely, spectral, amplitude modulation rate of change, coherence, and phase. The three AAR algorithms tested are statistical artifact rejection (SAR), blind source separation based on second order blind identification and canonical correlation analysis (BSS-SOBI-CCA), and wavelet enhanced independent component analysis (wICA). Experimental results based on 20-channel resting-awake EEG data collected from 59 participants (20 patients with mild AD, 15 with moderate-to-severe AD, and 24 age-matched healthy controls) showed the wICA algorithm alone outperforming other enhancement algorithm combinations across three tasks: diagnosis (control vs. mild vs. moderate), early detection (control vs. mild), and disease progression (mild vs. moderate), thus opening the doors for fully-automated systems that can assist clinicians with early detection of AD, as well as disease severity progression assessment.