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Original Research ARTICLE

Front. Aging Neurosci., 01 April 2014 | http://dx.doi.org/10.3389/fnagi.2014.00056

Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study

  • 1Neurology Unit, Hospital Álvarez-Buylla, Mieres, Spain
  • 2Morphology and Cellular Biology Department, Universidad de Oviedo, Oviedo, Spain
  • 3Instituto de Neurociencias, Universidad de Oviedo, Oviedo, Spain
  • 4Family Medicine, Hospital Álvarez-Buylla, Mieres, Spain
  • 5Nuclear Medicine, Hospital Universitario Central de Asturias, Oviedo, Spain
  • 6Instituto de Investigación Científica, Universidad Juárez del Estado de Durango, Durango, Mexico
  • 7Transcranial Magnetic Stimulation Unit, Sleep and Movement Disorders Clinic, Hospital General Dr. Manuel Gea González, Mexico City, Mexico

The [123I]ioflupane—a dopamine transporter radioligand—SPECT (DaT-SPECT) has proven to be useful in the differential diagnosis of tremor. Here, we investigate the diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT. Therefore, 30 patients with tremor and normal DaT-SPECT were followed up for 2 years. In 18 cases we were able to make a diagnosis. The residual 12 patients underwent a second DaT-SPECT, were then followed for additional 12 months and thereafter the diagnosis was reconsidered again. The final diagnoses included cases of essential tremor, dystonic tremor, multisystem atrophy, vascular parkinsonism, progressive supranuclear palsy, corticobasal degeneration, fragile X–associated tremor ataxia syndrome, psychogenic parkinsonism, iatrogenic parkinsonism and Parkinson's disease. However, for 6 patients the diagnosis remained uncertain. Larger series are needed to better establish the relative frequency of the different conditions behind these cases.

Keywords: DaTSPECT, tremor, Parkinson disease, Movement Disorders, SWEDD

Citation: Menéndez-González M, Tavares F, Zeidan N, Salas-Pacheco JM and Arias-Carrión O (2014) Diagnoses behind patients with hard-to-classify tremor and normal DaT-SPECT: a clinical follow up study. Front. Aging Neurosci. 6:56. doi: 10.3389/fnagi.2014.00056

Received: 28 January 2014; Accepted: 10 March 2014;
Published online: 01 April 2014.

Edited by:

Rodrigo Orlando Kuljiš, Zdrav Mozak Limitada, Chile

Reviewed by:

Junming Wang, University of Mississippi Medical Center, USA
Aruna Sharma, Uppsala University Hospital, Sweden

Copyright © 2014 Menéndez-González, Tavares, Zeidan, Salas-Pacheco and Arias-Carrión. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Manuel Menéndez-González, Neurology Unit, Hospital Álvarez-Buylla, Murias s/n, 33616, Mieres, Spain e-mail: manuelmenendezgonzalez@gmail.com;
Oscar Arias-Carrión, TMS Lab, Hospital General Dr. Manuel Gea González, Calzada de Tlalpan 4800, Mexico City 14080, Mexico e-mail: arias@ifc.unam.mx