Original Research ARTICLE
Design of a neurally plausible model of fear learning
- 1 Department of Psychology, University of California Los Angeles, Los Angeles, CA, USA
- 2 Brain Research Institute, University of California Los Angeles, Los Angeles, CA, USA
- 3 Department of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA, USA
A neurally oriented conceptual and computational model of fear conditioning manifested by freezing behavior (FRAT), which accounts for many aspects of delay and context conditioning, has been constructed. Conditioning and extinction are the result of neuromodulation-controlled LTP at synapses of thalamic, cortical, and hippocampal afferents on principal cells and inhibitory interneurons of lateral and basal amygdala. The phenomena accounted for by the model (and simulated by the computational version) include conditioning, secondary reinforcement, blocking, the immediate shock deficit, extinction, renewal, and a range of empirically valid effects of pre- and post-training ablation or inactivation of hippocampus or amygdala nuclei.
Keywords: fear, learning, conditioning, extinction, model, neural circuit, amygdala, hippocampus
Citation: Krasne FB, Fanselow MS and Zelikowsky M (2011) Design of a neurally plausible model of fear learning. Front. Behav. Neurosci. 5:41. doi: 10.3389/fnbeh.2011.00041
Received: 30 March 2011;
Accepted: 07 July 2011;
Published online: 26 July 2011.
Edited by:Jeansok J. Kim, University of Washington, USA
Reviewed by:Stephan G. Anagnostaras, University of California, San Diego, USA
Gavan McNally, University of New South Wales, Australia
Copyright: © 2011 Krasne, Fanselow and Zelikowsky. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
*Correspondence: Franklin B. Krasne, Department of Psychology, University of California Los Angeles, Los Angeles, CA 90095, USA. e-mail: firstname.lastname@example.org