Mini Review ARTICLE

Front. Behav. Neurosci., 19 June 2013 | doi: 10.3389/fnbeh.2013.00070

Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny

Samanta M. March1,2*, P. Abate1,2 and Juan C. Molina1,2*
  • 1Laboratorio de Alcohol, Ontogenia y Desarrollo, Instituto de Investigación Médica Mercedes y Martín Ferreyra, Córdoba, Argentina
  • 2Department de Psicología, Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina

Clinical and biomedical studies sustains the notion that early ontogeny is a vulnerable window to the impact of alcohol. Experiences with the drug during these stages increase latter disposition to prefer, use or abuse ethanol. This period of enhanced sensitivity to ethanol is accompanied by a high rate of activity in the central catalase system, which metabolizes ethanol in the brain. Acetaldehyde (ACD), the first oxidation product of ethanol, has been found to share many neurobehavioral effects with the drug. Cumulative evidence supports this notion in models employing adults. Nevertheless very few studies have been conducted to analyze the role of ACD in ethanol postabsorptive effects, in newborns or infant rats. In this work we review recent experimental literature that syndicates ACD as a mediator agent of reinforcing aspects of ethanol, during early ontogenetic stages. We also show a meta-analytical correlational approach that proposes how differences in the activity of brain catalase across ontogeny, could be modulating patterns of ethanol consumption.

Keywords: early ethanol exposure, acetaldehyde, ontogeny, learning, appetitive response, suckling, newborns, infants

Citation: March SM, Abate P and Molina JC (2013) Acetaldehyde involvement in ethanol's postabsortive effects during early ontogeny. Front. Behav. Neurosci. 7:70. doi: 10.3389/fnbeh.2013.00070

Received: 20 March 2013; Accepted: 01 June 2013;
Published online: 19 June 2013.

Edited by:

Merce Correa, Universitat Jaume, Spain

Reviewed by:

Merce Correa, Universitat Jaume, Spain
Sergey M. Zimatkin, Grodno State Medical University, Belarus
Marta Y. Pepino, Washington University School of Medicine, USA

Copyright © 2013 March, Abate and Molina. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

*Correspondence: Samanta M. March and Juan C. Molina, Laboratorio de Alcohol, Ontogenia y Desarrollo, Instituto de Investigación Médica Mercedes y Martín Ferreyra, Friuli 2434, PO Box 389, Córdoba, 5016, Argentina e-mail: smarch@immf.uncor.edu; juancmolina2003@yahoo.com

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