%A Tu,Sicong %A Miller,Laurie %A Piguet,Olivier %A Hornberger,Michael %D 2014 %J Frontiers in Behavioral Neuroscience %C %F %G English %K Thalamus,anterograde memory,Stroke,Mammillothalamic tract,MRI %Q %R 10.3389/fnbeh.2014.00320 %W %L %M %P %7 %8 2014-September-15 %9 Original Research %+ Michael Hornberger,Australian Research Council Centre of Excellence in Cognition and its Disorders,Sydney, NSW, Australia,mh755@medschl.cam.ac.uk %+ Michael Hornberger,Department of Clinical Neurosciences, University of Cambridge,Cambridge, UK,mh755@medschl.cam.ac.uk %+ Michael Hornberger,Neuroscience Research Australia, School of Medical Sciences, University of New South Wales,Sydney, NSW, Australia,mh755@medschl.cam.ac.uk %# %! Anterograde memory and thalamic stroke %* %< %T Accelerated forgetting of contextual details due to focal medio-dorsal thalamic lesion %U https://www.frontiersin.org/articles/10.3389/fnbeh.2014.00320 %V 8 %0 JOURNAL ARTICLE %@ 1662-5153 %X Effects of thalamic nuclei damage and related white matter tracts on memory performance are still debated. This is particularly evident for the medio-dorsal thalamus which has been less clear in predicting amnesia than anterior thalamus changes. The current study addresses this issue by assessing 7 thalamic stroke patients with consistent unilateral lesions focal to the left medio-dorsal nuclei for immediate and delayed memory performance on standard visual and verbal tests of anterograde memory, and over the long-term (>24 h) on an object-location associative memory task. Thalamic patients showed selective impairment to delayed recall, but intact recognition memory. Patients also showed accelerated forgetting of contextual details after a 24 h delay, compared to controls. Importantly, the mammillothalamic tract was intact in all patients, which suggests a role for the medio-dorsal nuclei in recall and early consolidation memory processes.