AUTHOR=Basilio Rodrigo, Garrido Griselda J., Sato João R., Hoefle Sebastian, Melo Bruno R. P., Pamplona Fabricio A., Zahn Roland, Moll Jorge TITLE=FRIEND Engine Framework: a real time neurofeedback client-server system for neuroimaging studies JOURNAL=Frontiers in Behavioral Neuroscience VOLUME=9 YEAR=2015 URL=https://www.frontiersin.org/articles/10.3389/fnbeh.2015.00003 DOI=10.3389/fnbeh.2015.00003 ISSN=1662-5153 ABSTRACT=In this methods article, we present a new implementation of a recently reported FSL-integrated neurofeedback tool, the standalone version of “Functional Real-time Interactive Endogenous Neuromodulation and Decoding” (FRIEND). We will refer to this new implementation as the FRIEND Engine Framework. The framework comprises a client-server cross-platform solution for real time fMRI and fMRI/EEG neurofeedback studies, enabling flexible customization or integration of graphical interfaces, devices, and data processing. This implementation allows a fast setup of novel plug-ins and frontends, which can be shared with the user community at large. The FRIEND Engine Framework is freely distributed for non-commercial, research purposes.