Schizophrenia is a neurodevelopment disorder in which the interplay of genes and environment contributes to disease onset and establishment. The most consistent pathological feature in schizophrenic patients is an enlargement of the brain ventricles. Yet, so far, no study has related this finding with dysfunction of the choroid plexus (CP), the epithelial cell monolayer located within the brain ventricles that is responsible for the production of most of the cerebrospinal fluid (CSF). Enlarged brain ventricles are already present at the time of disease onset (young adulthood) and, of notice, isolated mild ventriculomegaly detected in utero is associated with subsequent mild neurodevelopmental abnormalities similar to those observed in children at high risk of developing schizophrenia. Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia.
Keywords: neurodevelopment, choroid plexus, schizophrenia, cerebrospinal fluid, brain ventricles, ventriculomegaly
Citation: Palha JA, Santos NC, Marques F, Sousa J, Bessa J, Miguelote R, Sousa N and Belmonte-de-Abreu P (2012) Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia. Front. Cell. Neurosci. 6:31. doi: 10.3389/fncel.2012.00031
Received: 10 February 2012; Accepted: 15 July 2012;
Published online: 08 August 2012.
Edited by:Egidio D'Angelo, University of Pavia, Italy
Reviewed by:Barbara Wroblewska, Georgetown University, USA
Copyright © 2012 Palha, Santos, Marques, Sousa, Bessa, Miguelote, Sousa and Belmonte-de-Abreu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Joana A. Palha, Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. e-mail: firstname.lastname@example.org