@ARTICLE{10.3389/fncir.2013.00016, AUTHOR={Molkov, Yaroslav and Bacak, Bartholomew and Dick, Thomas and Rybak, Ilya}, TITLE={Control of breathing by interacting pontine and pulmonary feedback loops}, JOURNAL={Frontiers in Neural Circuits}, VOLUME={7}, YEAR={2013}, URL={https://www.frontiersin.org/articles/10.3389/fncir.2013.00016}, DOI={10.3389/fncir.2013.00016}, ISSN={1662-5110}, ABSTRACT={The medullary respiratory network generates respiratory rhythm via sequential phase switching, which in turn is controlled by multiple feedbacks including those from the pons and nucleus tractus solitarii; the latter mediates pulmonary afferent feedback to the medullary circuits. It is hypothesized that both pontine and pulmonary feedback pathways operate via activation of medullary respiratory neurons that are critically involved in phase switching. Moreover, the pontine and pulmonary control loops interact, so that pulmonary afferents control the gain of pontine influence of the respiratory pattern. We used an established computational model of the respiratory network (Smith et al., 2007) and extended it by incorporating pontine circuits and pulmonary feedback. In the extended model, the pontine neurons receive phasic excitatory activation from, and provide feedback to, medullary respiratory neurons responsible for the onset and termination of inspiration. The model was used to study the effects of: (1) “vagotomy” (removal of pulmonary feedback), (2) suppression of pontine activity attenuating pontine feedback, and (3) these perturbations applied together on the respiratory pattern and durations of inspiration (TI) and expiration (TE). In our model: (a) the simulated vagotomy resulted in increases of both TI and TE, (b) the suppression of pontine-medullary interactions led to the prolongation of TI at relatively constant, but variable TE, and (c) these perturbations applied together resulted in “apneusis,” characterized by a significantly prolonged TI. The results of modeling were compared with, and provided a reasonable explanation for, multiple experimental data. The characteristic changes in TI and TE demonstrated with the model may represent characteristic changes in the balance between the pontine and pulmonary feedback control mechanisms that may reflect specific cardio-respiratory disorders and diseases.} }