Front. Neurol., 23 August 2010 |

Comorbidities of migraine

  • 1 Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan
  • 2 National Yang-Ming University School of Medicine, Taipei, Taiwan
  • 3 Department of Neurology, Lin-Shin Hospital, Taichung, Taiwan
  • 4 Graduate Institute of Clinical Medicine Science, China Medical University, Taichung, Taiwan

Migraine is a common neurological disorder and can be severely disabling during attacks. The highest prevalence occurs between the ages of 25 and 55 years, potentially the most productive period of life. Migraine leads to a burden not only for the individual, but also for the family and society in general. Prior studies have found that migraine occurs together with other illnesses at a greater coincidental rate than is seen in the general population. These occurrences are called “comorbidities,” which means that these disorders are interrelated with migraine. To delineate the comorbidities of migraine is important, because it can help improve treatment strategies and the understanding of the possible pathophysiology of migraine. The comorbid illnesses in patients with migraine include stroke, sub-clinical vascular brain lesions, coronary heart disease, hypertension, patent foramen ovale, psychiatric diseases (depression, anxiety, bipolar disorder, panic disorder, and suicide), restless legs syndrome, epilepsy and asthma. In this paper, we review the existing epidemiological and hospital-based studies, and illustrate the connections between these illnesses and migraine.

Keywords: migraine, cerebrovascular disorder, depression, anxiety, comorbidity

Citation: Wang S-J, Chen P-K and Fuh J-L (2010) Comorbidities of migraine. Front. Neur. 1:16. doi: 10.3389/fneur.2010.00016

Received: 05 March 2010; Paper pending published: 29 April 2010;
Accepted: 28 June 2010; Published online: 23 August 2010

Edited by:

Mario Peres, Instituto Israelita de Ensino e Pesquisa Albert Einstein, Brazil

Reviewed by:

Giancarlo Luchetti, Centro de Terapia Intensiva, Hospital de Aeronáutica de São Paulo, Brazil
Marcelo Valença, Federal University of Pernambuco, Brazil

Copyright: © 2010 Wang, Chen and Fuh. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

*Correspondence: Shuu-Jiun Wang, Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, Taipei 112, Taiwan. e-mail: