Review ARTICLE

Front. Neurol., 14 July 2011 | http://dx.doi.org/10.3389/fneur.2011.00044

Endovascular therapy for chronic cerebrospinal venous insufficiency in multiple sclerosis

Marc A. Lazzaro1*, Osama O. Zaidat1,2,3, Nils Mueller-Kronast4*, Muhammad A. Taqi1 and Douglas Woo1*
  • 1 Department of Neurology, Froedtert Hospital and Medical College of Wisconsin, Milwaukee, WI, USA
  • 2 Department of Neurosurgery, Froedtert Hospital and Medical College of Wisconsin, Milwaukee, WI, USA
  • 3 Department of Radiology, Froedtert Hospital and Medical College of Wisconsin, Milwaukee, WI, USA
  • 4 Department of Neurology, Delray Medical Center, Delray Beach, FL, USA

Recent reports have emerged suggesting that multiple sclerosis (MS) may be due to abnormal venous outflow from the central nervous system, termed chronic cerebrospinal venous insufficiency (CCSVI). These reports have generated strong interest and controversy over the prospect of a treatable cause of this chronic debilitating disease. This review aims to describe the proposed association between CCSVI and MS, summarize the current data, and discuss the role of endovascular therapy and the need for rigorous randomized clinical trials to evaluate this association and treatment.

Keywords: angioplasty, stent, jugular, azygos, stenosis, CCSVI, MS

Citation: Lazzaro MA, Zaidat OO, Mueller-Kronast N, Taqi MA and Woo D (2011) Endovascular therapy for chronic cerebrospinal venous insufficiency in multiple sclerosis. Front. Neur. 2:44. doi: 10.3389/fneur.2011.00044

Received: 03 May 2011; Accepted: 28 June 2011;
Published online: 14 July 2011.

Edited by:

Randall Edgell, Saint Louis University, USA

Reviewed by:

Ashish Nanda, University of Missouri, USA
Edgard Pereira, JFK Medical Center, USA

Copyright: © 2011 Lazzaro, Zaidat, Mueller-Kronast, Taqi and Woo. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

*Correspondence: Marc A. Lazzaro and Douglas Woo, Department of Neurology, Froedtert Hospital and Medical College of Wisconsin, 9200 West Wisconsin Avenue, Milwaukee, WI 53226, USA. e-mail: mlazzaro2@gmail.com; dwoo@mcw.edu; Nils Mueller-Kronast, Department of Neurology, Delray Medical Center, 5162 Linton Boulevard 106, Delray Beach, FL 33484, USA. e-mail: muellerkronast@gmail.com