Muscle diseases can constitute a large variety of both acquired and hereditary disorders. Myopathies in systemic disease results from several different disease processes including endocrine, inflammatory, paraneoplastic, infectious, drug- and toxin-induced, critical illness myopathy, metabolic, and myopathies with other systemic disorders. Patients with systemic myopathies often present acutely or sub acutely. On the other hand, familial myopathies or dystrophies generally present in a chronic fashion with exceptions of metabolic myopathies where symptoms on occasion can be precipitated acutely. Most of the inflammatory myopathies can have a chance association with malignant lesions; the incidence appears to be specifically increased only in patients with dermatomyositis. In dealing with myopathies associated with systemic illnesses, the focus will be on the acquired causes. Management is beyond the scope of this chapter. Prognosis is based upon the underlying cause and, most of the time, carries a good prognosis. In order to approach a patient with suspected myopathy from systemic disease, a stepwise approach is utilized.
Keywords: CK, EMG, HyperCKemia, IVIgG, CIM, HMG-CoA, HIV
Citation: Chawla J (2011) Stepwise approach to myopathy in systemic disease. Front. Neur. 2:49. doi: 10.3389/fneur.2011.00049
Received: 13 March 2011;
Accepted: 14 July 2011;
Published online: 05 August 2011.
Edited by:Guy Rouleau, University of Montreal, Canada
Reviewed by:Nicolas Dupre, Laval University, Canada
Copyright: © 2011 Chawla. This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.
*Correspondence: Jasvinder Chawla, Chief of Neurology, Hines VA Hospital and Neurology Residency Program Director, Loyola University Medical Center, Hines, IL, USA. e-mail: firstname.lastname@example.org