Perspective ARTICLE

Front. Neurol., 02 February 2012 | doi: 10.3389/fneur.2012.00003

Bench-to-bedside and bedside back to the bench; coordinating clinical and experimental traumatic brain injury studies

  • 1 Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
  • 2 Experimental Traumatology, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
  • 3 Department of Clinical Neuroscience, Section for Neurosurgery, Karolinska University Hospital, Solna, Sweden

Traumatic brain injury (TBI) is one of the leading cause of death and long-term disability in virtually every country. Advances in neurointensive care have resulted in steadily decreasing morbidity, but the number of individuals with severe long-term disability have not changed significantly and the number of moderate disability has shown steady increase over the last 3 decades. Despite years of intensive preclinical research – and millions spent – there are virtually no drugs specifically developed to mitigate the consequences of TBI. Here we discuss some of the existing gaps between clinical and experimental TBI studies that may have contributed to the current status. We do this hoping that clinical, basic, and translational scientists will design and coordinate studies in order to achieve maximum benefits for TBI patients. In conclusion, we suggest to: (1) Develop consensus-based guidelines for experimental TBI research, similar to “best practices” in the clinic; (2) Generate a consensus-based template for clinical data collection and deposition as well as for experimental TBI data collection and deposition; (3) Use a systems biology approach and create a database for integrating existing data from basic and clinical research.

Keywords: neurotrauma, clinical, experimental, gaps

Citation: Agoston DV, Risling M and Bellander B-M (2012) Bench-to-bedside and bedside back to the bench; coordinating clinical and experimental traumatic brain injury studies. Front. Neur. 3:3. doi: 10.3389/fneur.2012.00003

Received: 18 October 2011; Paper pending published: 25 November 2011;
Accepted: 03 January 2012; Published online: 02 February 2012.

Edited by:

Mattias Sköld, Uppsala University, Sweden

Reviewed by:

Charmaine Childs, National University of Singapore, Singapore
Fredrik Clausen, Uppsala University, Sweden

Copyright: © 2012 Agoston, Risling and Bellander. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Denes V. Agoston, Experimental Traumatology, Department of Neuroscience Karolinska Institutet, Stockholm, Sweden. e-mail:

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