Hypothesis & Theory ARTICLE
Hypothesis: cryptochromes and brown fat are essential for adaptation and affect mood and mood-related behaviors
- 1Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
- 2Department of Psychiatry, University of Helsinki, Helsinki, Finland
Solar radiation and ambient temperature have acted as selective physical forces among populations and thereby guided species distributions in the globe. Circadian clocks are universal and evolve when subjected to selection, and their properties contribute to variations in fitness within specific environments. Concerning humans, as compared to the remaining, the “evening owls” have a greater deviation from the 24 h cycle, are under a greater pressure to circadian desynchrony and more prone to a cluster of health hazards with the increased mortality. Because of their position in the hierarchy and repressive actions, cryptochromes are the key components of the feedback loops on which circadian clocks are built. Based on the evidence a new hypothesis is formulated in which brown adipocytes with their cryptochromes are responsive to a broad range of physical stimuli from the habitat and through their activity ensure adaptation of the individual. The over-activated brown adipose tissue with deficient cryptochromes might induce disrupted thermoregulation and circadian desynchrony, and thereby contribute to lowered mood and pronounced depressive behaviors.
Keywords: basic rest-activity cycle, brown fat, clock, diurnal, evolution, natural selection
Citation: Partonen T (2012) Hypothesis: cryptochromes and brown fat are essential for adaptation and affect mood and mood-related behaviors. Front. Neur. 3:157. doi: 10.3389/fneur.2012.00157
Received: 10 August 2012; Paper pending published: 17 September 2012;
Accepted: 16 October 2012; Published online: 05 November 2012.
Edited by:Mehmet Y. Agargün, Yüzüncü Yil University School of Medicine, Turkey
Reviewed by:Nirinjini Naidoo, University of Pennsylvania, USA
Vijay Kumar Sharma, Jawaharlal Nehru Centre for Advanced Scientific Research, India
Copyright: © 2012 Partonen. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Timo Partonen, Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, P.O. Box 30, Mannerheimintie 166, FI-00271 Helsinki, Finland. e-mail: firstname.lastname@example.org