Neurological and psychiatric sequelae of developmental exposure to antiepileptic drugs
- Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
The neurons in the developing mammalian brain are susceptible to antiepileptic drug (AED) effects. It is known that later in life deficits in cognitive performance as well as psychiatric deficits can manifest after early AED exposure. The extent of these deficits will be addressed. This review will attempt to draw parallels between the existent animal models and human studies. Through analysis of these studies, important future research will be elucidated and possible new and emerging therapies will be discussed.
Keywords: antiepileptic, neurodevelopmental, neuronal plasticity, teratogenicity, fetal, neurotransmitter
Citation: Gedzelman ER and Meador KJ (2012) Neurological and psychiatric sequelae of developmental exposure to antiepileptic drugs. Front. Neur. 3:182. doi: 10.3389/fneur.2012.00182
Received: 01 September 2012; Accepted: 10 December 2012;
Published online: 27 December 2012.
Edited by:Karen Gale, Georgetown University, USA
Reviewed by:Yushi Inoue, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
Jeffrey M. Chung, Cedars-Sinai Medical Center, USA
Gholam K. Motamedi, Georgetown University Hospital, USA
Anne Zajicek, National Institutes of Health, USA
Copyright: © 2012 Gedzelman and Meador. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Evan R. Gedzelman and Kimford J. Meador, Department of Neurology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 6000, Atlanta, GA 30322, USA. e-mail: firstname.lastname@example.org; email@example.com