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Front. Hum. Neurosci., 06 January 2012 | http://dx.doi.org/10.3389/fnhum.2011.00181

Revisiting hydrocephalus as a model to study brain resilience

Matheus Fernandes de Oliveira*, Fernando Campos Gomes Pinto, Koshiro Nishikuni, Ricardo Vieira Botelho, Alessandra Moura Lima and José Marcus Rotta
  • Department of Neurosurgery, Hospital do Servidor Público Estadual de São Paulo, São Paulo, Brazil

Hydrocephalus is an entity which embraces a variety of diseases whose final result is the enlarged size of cerebral ventricular system, partially or completely. The physiopathology of hydrocephalus lies in the dynamics of circulation of cerebrospinal fluid (CSF). The consequent CSF stasis in hydrocephalus interferes with cerebral and ventricular system development. Children and adults who sustain congenital or acquired brain injury typically experience a diffuse insult that impacts many areas of the brain. Development and recovery after such injuries reflects both restoration and reorganization of cognitive functions. Classic examples were already reported in literature. This suggests the presence of biological mechanisms associated with resilient adaptation of brain networks. We will settle a link between the notable modifications to neurophysiology secondary to hydrocephalus and the ability of neuronal tissue to reassume and reorganize its functions.

Keywords: hydrocephalus, resilience, brain, neural networks, plasticity

Citation: de Oliveira MF, Pinto FCG, Nishikuni K Botelho RV, Lima AM and Rotta JM (2012) Revisiting hydrocephalus as a model to study brain resilience. Front. Hum. Neurosci. 5:181. doi: 10.3389/fnhum.2011.00181

Received: 18 October 2011; Paper pending published: 25 November 2011;
Accepted: 18 December 2011; Published online: 06 January 2012.

Edited by:

João Ricardo Mendes Oliveira, Federal University of Pernambuco, Brazil

Reviewed by:

João Ricardo Mendes Oliveira, Federal University of Pernambuco, Brazil
Carlos Augusto Carvalho De Vasconcelos, Federal University of Pernambuco, Brazil

Copyright: © 2012 de Oliveira, Pinto, Nishikuni, Botelho, Lima and Rotta. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Matheus Fernandes de Oliveira, Hospital do Servidor Público Estadual de São Paulo, Avenue Pedro de Toledo, 1800, Vila Clementino, São Paulo, Brazil. e-mail: mafernoliv@yahoo.com.br