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This article is part of the Research Topic Brain Connectivity in Autism

Review ARTICLE

Front. Hum. Neurosci., 07 August 2013 | http://dx.doi.org/10.3389/fnhum.2013.00458

Reconceptualizing functional brain connectivity in autism from a developmental perspective

  • 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
  • 2Program in Neuroscience, Stanford University School of Medicine, Stanford, CA, USA
  • 3Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA

While there is almost universal agreement amongst researchers that autism is associated with alterations in brain connectivity, the precise nature of these alterations continues to be debated. Theoretical and empirical work is beginning to reveal that autism is associated with a complex functional phenotype characterized by both hypo- and hyper-connectivity of large-scale brain systems. It is not yet understood why such conflicting patterns of brain connectivity are observed across different studies, and the factors contributing to these heterogeneous findings have not been identified. Developmental changes in functional connectivity have received inadequate attention to date. We propose that discrepancies between findings of autism related hypo-connectivity and hyper-connectivity might be reconciled by taking developmental changes into account. We review neuroimaging studies of autism, with an emphasis on functional magnetic resonance imaging studies of intrinsic functional connectivity in children, adolescents and adults. The consistent pattern emerging across several studies is that while intrinsic functional connectivity in adolescents and adults with autism is generally reduced compared with age-matched controls, functional connectivity in younger children with the disorder appears to be increased. We suggest that by placing recent empirical findings within a developmental framework, and explicitly characterizing age and pubertal stage in future work, it may be possible to resolve conflicting findings of hypo- and hyper-connectivity in the extant literature and arrive at a more comprehensive understanding of the neurobiology of autism.

Keywords: autism spectrum disorders, brain development, functional connectivity, puberty, fMRI

Citation: Uddin LQ, Supekar K and Menon V (2013) Reconceptualizing functional brain connectivity in autism from a developmental perspective. Front. Hum. Neurosci. 7:458. doi: 10.3389/fnhum.2013.00458

Received: 18 April 2013; Accepted: 22 July 2013;
Published online: 07 August 2013.

Edited by:

Rajesh K. Kana, University of Alabama at Birmingham, USA

Reviewed by:

Qingbao Yu, The Mind Research Network, USA
R. Matthew Hutchison, Western University, Canada
Timothy A. Keller, Carnegie Mellon University, USA
Diane L. Williams, Duquesne University, USA

Copyright © 2013 Uddin, Supekar and Menon. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Lucina Q. Uddin, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Rd., Stanford, CA 94305-5719, USA e-mail: lucina@stanford.edu