Impact Factor

Original Research ARTICLE

Front. Hum. Neurosci., 25 December 2013 | http://dx.doi.org/10.3389/fnhum.2013.00884

Neurophysiological and behavioral responses to music therapy in vegetative and minimally conscious states

imageJulian O’Kelly1,2*, imageL. James1, imageR. Palaniappan3, imageJ. Taborin4, imageJ. Fachner5 and imageW. L. Magee6
  • 1Research Department, Royal Hospital for Neuro-disability, London, UK
  • 2Department of Communication and Psychology, Aalborg University, Aalborg, Denmark
  • 3Faculty of Science and Engineering, Wolverhampton University, Wolverhampton, UK
  • 4Department of Neuroscience, King’s College London, London, UK
  • 5Department of Music and Performing Arts, Anglia Ruskin University, Cambridge, UK
  • 6Boyer College of Music and Dance, Temple University Philadelphia, Philadelphia, PA, USA

Assessment of awareness for those with disorders of consciousness is a challenging undertaking, due to the complex presentation of the population. Debate surrounds whether behavioral assessments provide greatest accuracy in diagnosis compared to neuro-imaging methods, and despite developments in both, misdiagnosis rates remain high. Music therapy may be effective in the assessment and rehabilitation with this population due to effects of musical stimuli on arousal, attention, and emotion, irrespective of verbal or motor deficits. However, an evidence base is lacking as to which procedures are most effective. To address this, a neurophysiological and behavioral study was undertaken comparing electroencephalogram (EEG), heart rate variability, respiration, and behavioral responses of 20 healthy subjects with 21 individuals in vegetative or minimally conscious states (VS or MCS). Subjects were presented with live preferred music and improvised music entrained to respiration (procedures typically used in music therapy), recordings of disliked music, white noise, and silence. ANOVA tests indicated a range of significant responses (p ≤ 0.05) across healthy subjects corresponding to arousal and attention in response to preferred music including concurrent increases in respiration rate with globally enhanced EEG power spectra responses (p = 0.05–0.0001) across frequency bandwidths. Whilst physiological responses were heterogeneous across patient cohorts, significant post hoc EEG amplitude increases for stimuli associated with preferred music were found for frontal midline theta in six VS and four MCS subjects, and frontal alpha in three VS and four MCS subjects (p = 0.05–0.0001). Furthermore, behavioral data showed a significantly increased blink rate for preferred music (p = 0.029) within the VS cohort. Two VS cases are presented with concurrent changes (p ≤ 0.05) across measures indicative of discriminatory responses to both music therapy procedures. A third MCS case study is presented highlighting how more sensitive selective attention may distinguish MCS from VS. The findings suggest that further investigation is warranted to explore the use of music therapy for prognostic indicators, and its potential to support neuroplasticity in rehabilitation programs.

Keywords: EEG, music therapy, disorders of consciousness, assessment, diagnosis, brain injury, vegetative state, minimally conscious state

Citation: O’Kelly J, James L, Palaniappan R, Taborin J, Fachner J and Magee WL (2013) Neurophysiological and behavioral responses to music therapy in vegetative and minimally conscious states. Front. Hum. Neurosci. 7:884. doi: 10.3389/fnhum.2013.00884

Received: 30 October 2013; Accepted: 05 December 2013;
Published online: 25 December 2013.

Edited by:

Teppo Särkämö, University of Helsinki, Finland

Reviewed by:

Rita Formisano, Santa Lucia Foundation, Italy
Jeanette Tamplin, University of Melbourne, Australia

Copyright: © 2013 O’Kelly, James, Palaniappan, Taborin, Fachner and Magee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Julian O’Kelly, Research Department, Royal Hospital for Neuro-disability, West Hill, London SW15 3SW, UK e-mail: jokelly@rhn.org.uk