TY - JOUR AU - Klöppel, Stefan AU - Lauer, Eliza AU - Peter, Jessica AU - Minkova, Lora AU - Nissen, Christoph AU - Normann, Claus AU - Reis, Janine AU - Mainberger, Florian AU - Bach, Michael AU - Lahr, Jacob PY - 2015 M3 - Original Research TI - LTP-like plasticity in the visual system and in the motor system appear related in young and healthy subjects JO - Frontiers in Human Neuroscience UR - https://www.frontiersin.org/articles/10.3389/fnhum.2015.00506 VL - 9 SN - 1662-5161 N2 - LTP-like plasticity measured by visual evoked potentials (VEP) can be induced in the intact human brain by presenting checkerboard reversals. Also associated with LTP-like plasticity, around two third of participants respond to transcranial magnetic stimulation (TMS) with a paired-associate stimulation (PAS) protocol with a potentiation of their motor evoked potentials. LTP-like processes are also required for verbal and motor learning tasks. We compared effect sizes, responder rates and intercorrelations as well as the potential influence of attention between these four assessments in a group of 37 young and healthy volunteers. We observed a potentiation effect of the N75 and P100 VEP component which positively correlated with plasticity induced by PAS. Subjects with a better subjective alertness were more likely to show PAS and VEP potentiation. No correlation was found between the other assessments. Effect sizes and responder rates of VEP potentiation were higher compared to PAS. Our results indicate a high variability of LTP-like effects and no evidence for a system-specific nature. As a consequence, studies wishing to assess individual levels of LTP-like plasticity should employ a combination of multiple assessments. ER -