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Original Research ARTICLE

Front. Neuroinform., 14 March 2014 | http://dx.doi.org/10.3389/fninf.2014.00024

BROCCOLI: Software for fast fMRI analysis on many-core CPUs and GPUs

  • 1Virginia Tech Carilion Research Institute, Virginia Tech, Roanoke, VA, USA
  • 2Department of Medical Imaging, University of Toronto, Toronto, ON, Canada
  • 3Division of Statistics, Department of Computer and Information Science, Linköping University, Linköping, Sweden
  • 4School of Biomedical Engineering and Sciences, Virginia Tech-Wake Forest University, Blacksburg, VA, USA

Analysis of functional magnetic resonance imaging (fMRI) data is becoming ever more computationally demanding as temporal and spatial resolutions improve, and large, publicly available data sets proliferate. Moreover, methodological improvements in the neuroimaging pipeline, such as non-linear spatial normalization, non-parametric permutation tests and Bayesian Markov Chain Monte Carlo approaches, can dramatically increase the computational burden. Despite these challenges, there do not yet exist any fMRI software packages which leverage inexpensive and powerful graphics processing units (GPUs) to perform these analyses. Here, we therefore present BROCCOLI, a free software package written in OpenCL (Open Computing Language) that can be used for parallel analysis of fMRI data on a large variety of hardware configurations. BROCCOLI has, for example, been tested with an Intel CPU, an Nvidia GPU, and an AMD GPU. These tests show that parallel processing of fMRI data can lead to significantly faster analysis pipelines. This speedup can be achieved on relatively standard hardware, but further, dramatic speed improvements require only a modest investment in GPU hardware. BROCCOLI (running on a GPU) can perform non-linear spatial normalization to a 1 mm3 brain template in 4–6 s, and run a second level permutation test with 10,000 permutations in about a minute. These non-parametric tests are generally more robust than their parametric counterparts, and can also enable more sophisticated analyses by estimating complicated null distributions. Additionally, BROCCOLI includes support for Bayesian first-level fMRI analysis using a Gibbs sampler. The new software is freely available under GNU GPL3 and can be downloaded from github (https://github.com/wanderine/BROCCOLI/).

Keywords: Neuroimaging, fMRI, Spatial normalization, GPU, CUDA, OpenCL, Image registration, Permutation test

Citation: Eklund A, Dufort P, Villani M and LaConte S (2014) BROCCOLI: Software for fast fMRI analysis on many-core CPUs and GPUs. Front. Neuroinform. 8:24. doi: 10.3389/fninf.2014.00024

Received: 09 December 2013; Accepted: 24 February 2014;
Published online: 14 March 2014.

Edited by:

Xi Cheng, Lieber Institue for Brain Development, USA

Reviewed by:

Roy Ben-Shalom, Bar-Ilan University, Israel
Moises Hernandez Fernandez, The Oxford Centre for Functional MRI of the Brain, UK

Copyright © 2014 Eklund, Dufort, Villani and LaConte. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Anders Eklund, Virginia Tech Carilion Research Institute, Virginia Tech, 2 Riverside Circle, Roanoke, 240 16 VA, USA e-mail: andek034@gmail.com