Technology Report ARTICLE
BrainBrowser: distributed, web-based neurological data visualization
- McGill Centre for Integrative Neuroscience, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada
In recent years, neuroimaging research has seen itself inundated by large, distributed datasets that have necessitated a shift in how scientists approach their research: guiding hypotheses are often articulated after analyzing the mass of available data (Margulies et al., 2013), and data sharing has become a necessity for scientific discovery (Jomier et al., 2011). Several large-scale, distributed, collaborative platforms have been developed to facilitate this new approach, and they tend to integrate poorly with traditional visualization tools requiring a local installation and local data. These tools and their dependencies would have to be installed locally, and data would generally have to be exported from the platform in order to be visualized in the local environment. Web-based visualization tools, on the other hand, present significant benefits in the context of distributed research platforms:
• They can be easily integrated into existing web-based platforms.
• Other than the web browser, no software or libraries need to be installed.
• If a visualization doesn't require the entirety of a remote dataset at once, it can load required data on-demand, potentially saving bandwidth.
Ideally, a web-based visualization tool might have the following properties:
• Performant and responsive: If network latency or lagging performance interfere with usability, researchers will not use it.
• Doesn't require any browser plugins (e.g., Java, Flash): Plugins add extra friction to the deployment of tools that depend on them. They require users to install software on their machines and keep it up to date. Furthermore, not all users have the administrative access to their machines that is required to install most plugins.
• Dynamic and interactive: If the tool is to be used to explore data, it should allow that data to be loaded, removed, manipulated and modified with minimal effort.
• Extensible: Many labs use different data formats, standards and requirements can change rapidly, so the tool should be able to adapt.
• Open source: It's easier for researchers to trust the results they're seeing if they can verify how the tool is functioning. If need be, they can also extend, customize and tweak the tool to fit their needs.
The fact that these technologies are now a part of the hyper-connected web platform has also made it possible to consider using visualization technologies in novel ways:
• Publication: With scientific articles now being published online, publishers are looking for ways to disseminate datasets and present them in more meaningful ways (Jomier et al., 2011). It is now possible to replace the static visual media of traditional print publications, such as static figures or charts, with more dynamic, interactive 2D or 3D visualizations1.
• Distribution: Online visualization tools can also be used as a means to distribute data, as researchers can use the tools to explore a remote dataset directly. BrainBrowser, for example, was used to share the MACACC dataset, as will be discussed further in Section 4.1. TissueStack, which will be discussed in Section 2, was used for remote visualization of the BigBrain dataset (Amunts et al., 2013) upon its release.
As will be discussed in Section 2, approaches to using the aforementioned web technologies for visualization can be broadly split into two categories. The first requires some back-end infrastructure to support a front-end client. This infrastructure will usually involve some processing of the data to be served, and might also include some proxying or database support. The second runs completely in the browser, requiring the back end to do nothing more than serve static files. BrainBrowser takes the latter approach for the following reasons:
1. Scalability: Both approaches require that the resources available on the server be capable of handling the user load at all times, but a fully front-end application puts a much lighter load on those resources. For back-end infrastructure, growth of the user base necessitates an expansion of infrastructure resources to prevent the application from blocking. In a commercial setting, where new users bring increased revenues, this type of expansion might not be considered problematic. In a research setting, however, where the relationship between users and revenue is not so direct, the cost of scaling becomes a major concern.
2. Network latency: If simple manipulations of a visualization require continuous network traffic, the responsiveness of the application will be bound by network latency. After the initial load of the data to be visualized, most fully front-end applications will no longer be dependent on the network.
3. Flexibility: Being independent of any particular server allows a fully front-end application to pull its data from essentially anywhere. An application could allow users visualize data they have stored locally on their machines without being required to upload them to a server. There is also nothing preventing fully front-end application from requesting data from a server with more elaborate infrastructure, thus allowing it to benefit from both approaches.
BrainBrowser has been developed to facilitate the exploitation of modern web technologies for a wide range of purposes. It exposes an application programming interface (API) that is simple enough to create a basic, interactive visualization in a few lines of code, while being deep enough to build more complex visualizations involving dynamic, on-demand fetching and loading of remote data. It uses WebGL, the HTML5 Canvas and Web Workers to push as much of the processing client-side as possible, thus minimizing the effect of network lag on its usage and eliminating the need for browser plugins. BrainBrowser is an open-source project, meaning that its users can verify the code directly and even modify it to fit their needs.
2. Related Work
Early attempts at advanced web-based visualization required plugins of one form or another, as standard web technologies could not provide the functionality and performance required for more advanced applications. The Java Internet Viewer (JIV, Cocosco and Evans, 2001) is an example of this type of solution. JIV could run as a standalone application or as a Java applet embedded in a web page. JIV presented the user with three orthogonal slices of a MINC volume that could be navigated by manipulating a cursor on each of the slices.
As more advanced web standards were proposed and implemented, many research groups began to show an interest in exploiting the new robustness of the web platform for various forms of advanced visualization. Google Body (now Zygote body, Blume et al., 2011) was an early example of what had become possible. Google Body renders several layers of a human body, from muscle tissues to blood vessels, and allows layers to be manipulated (e.g., by toggling their visibility or rendering them transparently) to facilitate viewing.
In the domain of neuroimaging, several tools have been developed, each offering a different approach to the problem of visualization. We present here a few examples that we believe exemplify the two approaches, back-end infrastructure and fully front-end, that were discussed in Section 1:
ParaViewWeb (Jourdain et al., 2011) functions as a web client for ParaView2, an open-source, server-side, parallel data visualization framework. ParaView uses the Visualization Toolkit3 (VTK) to generate visualizations on the server that the ParaViewWeb client interacts with through a web service proxy.
TissueStack4 (Lin et al., 2013) is an open-source application for visualizing MINC and NIfTI (Cox et al., 2004) files on the web. It is composed of an image server that tiles the volume to be visualized, a configuration database and an HTML5-based client for rendering the tiles.
Papaya6, like XTK, is an open-source visualization tool that operates completely in the browser. Unlike XTK, however, Papaya is implemented as an independent application rather than a library. It uses the 2D HTML5 Canvas API to implement an orthogonal viewer for NIfTI volumetric data that can be navigated using the keyboard or mouse. Users can manipulate the color mapping and thresholding of the intensity data being displayed.
3. Materials and Methods
3.1. Core Technologies
The HTML5 Canvas element is a high-performance, scriptable 2D drawing surface. Originally introduced by Apple in their Safari browser, it was eventually standardized by the Web Hypertext Application Working Group7 (WHATWG). The canvas element provides both a 2D drawing context exposing an API for drawing basic 2D shapes and images, and a WebGL context exposing an API for high-performance 3D graphics. The key aspect of the 2D API used by BrainBrowser is a set of functions for pixel-level image processing and manipulations. The Volume Viewer makes heavy use of this functionality to colorize and render volume slices to the screen.
Much of this flexibility comes from the modular approach taken in BrainBrowser's design. The library has been built from several independent, interconnected layers. The BrainBrowser core contains modules and functions related to functionality required by both the Surface Viewer and Volume Viewer: data loading over the network or from the file system, color mapping of intensity data, event handling, data storage and various utility functions. Aside from this shared core, the Surface Viewer and Volume Viewer each contain modules encapsulating more specific functionality.
3.2.1. Surface viewer
2. Geometry data are sent to one of several Web Workers for parsing. Each supported file type in the Surface Viewer is associated with a Web Worker that can be spawned to convert a given geometry description into the geometry object model that the Surface Viewer uses internally (Listing 2). This architecture, in which one Web Worker is responsible for each data format, exposes a plugin framework that can be used to add support for other data formats. Adding support for a new format requires only the creation of a Web Worker script that can convert the new format into the Surface Viewer object model.
3. Once data are converted to the Surface Viewer object model, a final step is required before the data can be displayed. One of the weaknesses of the current WebGL specification is that indices describing how to build a mesh from individual vertices are limited to 16 bits in size. This puts a limit of 65536 vertices on indexed models in WebGL. The Surface Viewer is meant to handle datasets that fall well outside this limit (the DTI sample on the BrainBrowser website17, for example, contains 560674 vertices). To get around this problem, BrainBrowser will send model data to a second Web Worker that de-indexes the model data, essentially “unrolling” the indices so that simply traversing the list of vertices is sufficient to draw the model.
4. Once model data are prepared, they are passed to a high-performance three.js BufferGeometry object to prepare them for display. The Surface Viewer supports displaying models made out of polygons (used for most surfaces) or lines (used for tractography data). If normals or vertex colors are provided in the model description, they will also be passed to the BufferGeometry. Otherwise, the vertex colors will be set to gray, and the normals will be inferred from the geometry using available three.js utility methods. If several shapes were described in the input data, each shape will get its own BufferGeometry object. This allows each shape to be manipulated individually (to apply different opacity levels to different parts, for example) or collectively (for rotating the model as a whole, for example).
Listing 1. BrainBrowser API code to create an instance of the Surface Viewer and use it to load and display surface and intensity data.
If per-vertex intensity data are to be mapped to a loaded model, three additional steps are taken (Figure 4):
1. A color map file is loaded. Similarly to the model data, this can be either over the network or from the local file system. Since parsing color map files is an inexpensive operation, however, it is done directly in the main thread, rather than in a Web Worker.
2. The intensity data are loaded and parsed. Loading, as with the other forms of data described, can occur over the network or from the local file system. Parsing is done similarly to the geometry data, with separate Web Workers being implemented for each supported intensity data type. As with the geometry, this creates a plugin framework for intensity data support, making it straightforward to add support for new formats. Currently, plain-text, Freesurfer binary and Freesurfer ASC intensity data formats are supported.
3. The color map is used to assign a color to the intensity scalar associated with each vertex. The mapped colors are then applied to the BufferGeometry color buffer, which updates the model's colors on a per-vertex basis.
Once a model is loaded and colorized, it can be manipulated in several ways:
• Intuitive mouse and touch controls to rotate, pan and zoom.
• A wireframe view that provides a clearer view of a model's geometry.
• Setting opacity on different parts of the model to reveal internal elements.
• Loaded intensity data can be manipulated in various ways such as setting intensity thresholds for color mapping, blending multiple datasets and programmatically modifying the dataset itself.
A key feature of the Surface Viewer is the picking mechanism that it implements. A simple method call that takes arbitrary x and y coordinates on the canvas (defaulting to the current mouse position) will return information about the vertex rendered closest to the given point. Returned data includes:
• The index of the vertex in the list of vertices.
• The x, y, and z coordinates of the selected vertex.
• The specific shape in the model that contains the selected vertex.
This picking mechanism makes it possible to implement more complex interactions with a rendered model based on the specific vertex with which a user is interacting. The MACACC dataset viewer that will be discussed in Section 4.1, for example, uses picking to dynamically load intensity data based on the selected vertex.
3.2.2. Volume viewer
1. A color map is loaded via the network or the local file system. Unlike the Surface Viewer, the Volume Viewer requires the color map to be loaded beforehand as the volume is pure scalar intensity data, without any explicit geometry, so there can be no visualization without a color map.
2. A volume is loaded over the network or from the local file system. This data will be loaded in two parts: (a) the raw intensity data, (b) header information describing the dimensions of the data and relationship between the voxel and world coordinate spaces. Currently, only MINC data are directly supported, but similarly to the Surface Viewer, volume preparation is done with a plugin architecture that makes it straightforward to add support for other formats.
3. The color map is used to assign a color to the intensity scalar associated with each voxel. These colors are used the create the image rendered for a given slice through the volume.
4. Other options can also be set, including setting the panel size and creating an overlay view of the loaded models.
Listing 3. BrainBrowser API code to create an instance of the Volume Viewer and use it to load and display a MINC volume.
Once a volume is loaded, three orthogonal slices of the volume along the sagittal, transverse and coronal planes will be displayed on three separate canvases. Each canvas also renders a cursor indicating the current display position of the volume along the given plane. The view of the volume can be manipulated in the following ways:
• Moving the cursor using mouse or touch controls updates the displayed orthogonal slices in real time.
• If the volume is four-dimensional, the time dimension can be manipulated programmatically.
• Keyboard controls are also available for all dimensions to facilitate more precise navigation through the volume.
• The current position of cursor in the in volume can be retrieved in both voxel and world coordinates. The Volume Viewer provides methods that perform the conversion automatically.
• The distance in world coordinates between two points can be measured.
• Intensity thresholds can be set to focus on particular ranges.
If more than one volume is loaded, then the following functionalities also become available:
• The volumes can be combined into an overlaid view for comparison. The blending weights for each volume can be set to favor one or the other.
• The cursors can be synchronized across volumes to facilitate comparisons.
Any of these functionalities can be hooked into standard user interface callbacks for events such as clicks or text input to create more complex applications. To simplify the creation of such user interfaces when multiple volumes are loaded, the Volume Viewer also provides a templating mechanism that allows a single UI template to be defined and repeatedly instantiated for multiple volumes. The developer simply creates a template using standard HTML. When loading the volumes, the Volume Viewer fetches the template, instantiates the UI and then inserts the display canvases at the appropriate location.
BrainBrowser has already been deployed for web-based visualization on a variety of platforms. Here, we will discuss three cases that we believe highlight BrainBrowser's strengths.
4.1. The MACACC Dataset
The MACACC Dataset (Lerch et al., 2006) is a database of structural correlations across the cortex derived from the International Consortium for Brain Mapping (Mazziotta et al., 2001). Cortical thickness at each of 81924 3D locations were calculated using the CLASP algorithm (Kim et al., 2005). The MACACC Dataset contains maps for all cortical vertices for each of three vertex-wise morphological variables: thickness, area and volume. The total number of permutations encoded in the dataset is 81924 vertices × 9 blurring kernels × 3 morphological indices × 3 statistical indices for a total of 6.3 million data maps, requiring over 1TB of storage space. The MACACC dataset presents an ideal use case for BrainBrowser in that its size makes it extremely inconvenient to distribute or to visualize using traditional, locally installed tools. These tools would generally necessitate the transfer of the entire dataset to the machine on which it is to be visualized. BrainBrowser, on the other hand, makes it trivial to explore this dataset in an intuitive manner. The MACACC Viewer18 (Figure 6) uses the picking mechanism described in Section 3.2.1 to fetch vertex information based on the point where the user clicks on the screen. This vertex information is used to make a network request for the correlation map associated with the selected vertex and then use it to colorize the model. This dynamic fetching means that only the portion of the 1TB MACACC dataset associated with the selected vertex (approximately 455kB) is transferred over the network, thus minimizing bandwidth usage and increasing accessibility.
Figure 6. The MACACC Viewer: A viewer built using the BrainBrowser Surface Viewer to visualize the MACACC dataset (Lerch et al., 2006).
CBRAIN (Sherif et al., 2014) is a distributed, collaborative, web-based, grid computing platform developed at McGill University. CBRAIN has been in active production since 2009 and currently has over 250 users from 53 cities in 21 countries around the world. CBRAIN is a complex system comprised of many interconnected components, but there are four components in particular that are relevant to the discussion here:
• Users interact with CBRAIN through a web interface that can be accessed through any modern web browser.
• Data are connected to CBRAIN through Data Providers, which are essentially storage devices that might be at any controlled, secure, network-accessible location.
• CBRAIN is connected to several High Performance Computing Centers (HPCs) at several locations around the world.
• Installed on the HPCs are data-processing tools that researchers use to analyze or process their data.
The current production deployment of CBRAIN consists of 11 HPCs in Canada, Germany and Korea. CBRAIN provides over 100TB of storage on its central servers, and several external Data Providers for specific projects or institutions are also registered with the system. A typical workflow for a CBRAIN user might include the following steps:
1. Register data with CBRAIN. This can be done by either creating a new Data Provider or by uploading data to one that already exists.
2. Visualize data as a preparatory quality control step before submitting them to an HPC.
3. Submit a job to an HPC through the web interface. This typically involves selecting the processing tool one wishes to use and the HPC on which to run the job.
4. Once the job is complete, results are saved back to the user's account.
5. Visualize results as a means of ensuring their quality or otherwise interpreting them.
Early in CBRAIN's development, visualizing data for the second and final steps was found to be problematic. It would often require downloading the data to visualize them locally. The Java Image Viewer (JIV) was used for a time to allow users to view images online. Among other problems, the requirement that users install a Java plugin on their machine was an issue for the reasons outlined in Section 1. BrainBrowser was an ideal solution in this situation as it could be integrated directly into the web-based UI of the platform without requiring a plugin. The Volume Viewer has now completely replaced JIV for visualizing MINC files in CBRAIN, and the Surface Viewer is now used to visualize surface files produced by the CIVET processing pipeline (Ad-Dab'bagh et al., 2006).
LORIS (Das et al., 2011) is a web-based database system providing infrastructure to automate the flow of clinical data for complex multi-site neuroimaging studies. Initially developed to manage data for the NIH MRI Study of Normal Brain Development (Evans, 2006), LORIS has since been adapted and implemented in numerous decentralized large-scale studies internationally, such as 1000BRAINS19 (Caspers et al., 2014, Germany), IBIS20 (USA), NeuroDevNet21 (Canada), GUSTO22 (Singapore) and NIHPD23 (USA).
As an example of the type of data LORIS handles, the NIH MRI Study of Normal Brain Development (NIHPD) used LORIS to house and distribute 3TB of native and processed data for over 2000 MRI acquisitions. Medical doctors visualized this data throughout the project to assess the quality of incoming scans. As with CBRAIN, visualization using traditional tools was problematic for users of LORIS, and like CBRAIN, JIV was used for a time as a solution that was imperfect for the reasons mentioned above. Currently, MINC volume files are visualized in LORIS using the Volume Viewer, and the Surface Viewer is used to visualize any compatible data that are stored in the system.
The advent of big data in neurological research, and the new methodological approaches it necessitates, have lead to the development of large-scale, distributed platforms to facilitate its exploration. Modern web technologies such as HTML5 and WebGL, have made it possible to create web-based tools that integrate seamlessly into these new environments. Conversely, newly available technologies have opened doors to novel ways of using research data that were not previously possible. Interactive figures in online articles and online data exploration are two examples of such novel usage that were presented here.
Compared to the other web visualization solutions presented in Section 2, BrainBrowser differentiates itself on several fronts. BrainBrowser operates completely in the browser, which sets it apart from back-end infrastructure solutions like ParaViewWeb and TissueStack. A comparison of BrainBrowser to XTK and Papaya, the two other fully front-end solutions that were discussed, is given in Table 1.
BrainBrowser's modular construction, and the fact that its source code is freely available, make it easily extensible and modifiable to suit the needs of its users. New data-parsing Web Workers can easily be added to BrainBrowser to allow it to support new file formats. This, in fact, ties into one of the major goals for the future of BrainBrowser: to continue building our open-source development community24 so it can directly develop the features it requires, including support for new file formats.
Moving forward, we would like to explore using BrainBrowser to visualize larger datasets (the BigBrain dataset, for example) that are not as granular as the MACACC dataset but are too large to be loaded directly into the browser. This would likely entail connecting a BrainBrowser-based application to a server that performs more back-end processing of the data, as was discussed in Section 1. There is also an enormous space for collaborative data exploration that has yet to be investigated. Using new technologies such as Web Sockets25 or WebRTC26, it is possible to create real-time collaborative environments that will facilitate the exploration of shared data in ways that have been impossible until now.
5.1. Data Sharing
All source code for BrainBrowser is freely available on GitHub27 under the GNU Affero General Public License v328. Demonstrations of BrainBrowser functionality are available on the BrainBrowser website29.
Conflict of Interest Statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
This work has been funded by CANARIE, Canada's Advanced Research and Innovation Network30, and McGill University. In addition to the authors, we would like to thank BrainBrowser's open source development community for their contributions31. We would also like to thank Samir Das and Penelope Kostopoulos for their help in determining feature requirements for the Volume Viewer.
1. ^For example: http://onpub.cbs.mpg.de/role-brocas-area-language.html
Ad-Dab'bagh, Y., Lyttelton, O., Muehlboeck, J. S., Lepage, C., Einarson, D., Mok, K., et al. (2006). “The CIVET image-processing environment: a fully automated comprehensive pipeline for anatomical neuroimaging research,” in Proceedings of the 12th Annual Meeting of the Organization for Human Brain Mapping (Florence), S45.
Amunts, K., Lepage, C., Borgeat, L., Mohlberg, H., Dickscheid, T., Rousseau, M.-É., et al. (2013). BigBrain: an ultrahigh-resolution 3d human brain model. Science 340, 1472–1475. doi: 10.1126/science.1235381
Caspers, S., Moebus, S., Lux, S., Pundt, N., Schütz, H., Mühleisen, T. W., et al. (2014). Studying variability in human brain aging in a population-based German cohortrationale and design of 1000BRAINS. Front. Aging Neurosci. 6:149. doi: 10.3389/fnagi.2014.00149
Cocosco, C. A., and Evans, A. C. (2001). “Java internet viewer: a WWW tool for remote 3d medical image data visualization and comparison,” in Medical Image Computing and Computer-Assisted Intervention (Utrecht), 1415–1416.
Cox, R. W., Ashburner, J., Breman, H., Fissell, K., Haselgrove, C., Holmes, C. J., et al. (2004). “A (sort of) new image data format standard: NiFTI-1,” in 10th Annual Meeting of the Organization for Human Brain Mapping (Budapest), 13–17.
Hähn, D., Rannou, N., Ahtam, B., Grant, E., and Pienaar, R. (2014). “Neuroimaging in the browser using the X Toolkit,” in Frontiers in Neuroinformatics Conference Abstract: 5th INCF Congress of Neuroinformatics (Munich).
Jomier, J., Jourdain, S., Ayachit, U., and Marion, C. (2011). “Remote visualization of large datasets with MIDAS and ParaViewWeb,” in Proceedings of the 16th International Conference on 3D Web Technology (Paris), 147–150.
Jourdain, S., Ayachit, U., and Geveci, B. (2011). Paraviewweb, a web framework for 3d visualization and data processing. Int. J. Comput. Inf. Syst. Ind. Manage. Appl. 3, 870–877. Available online at: http://www.mirlabs.org/ijcisim/regular_papers_2011/Paper98.pdf
Kim, J. S., Singh, V., Lee, J. K., Lerch, J., Ad-Dab'bagh, Y., MacDonald, D., et al. (2005). Automated 3-d extraction and evaluation of the inner and outer cortical surfaces using a Laplacian map and partial volume effect classification. Neuroimage 27, 210–221. doi: 10.1016/j.neuroimage.2005.03.036
Lerch, J. P., Worsley, K., Shaw, W. P., Greenstein, D. K., Lenroot, R. K., Giedd, J., et al. (2006). Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from mri. Neuroimage 31, 993–1003. doi: 10.1016/j.neuroimage.2006.01.042
Lin, M. K., Nicolini, O., Waxenegger, H., Galloway, G. J., Ullmann, J. F., and Janke, A. L. (2013). Interpretation of medical imaging data with a mobile application: a mobile digital imaging processing environment. Front. Neurol. 4:85. doi: 10.3389/fneur.2013.00085
Mazziotta, J., Toga, A., Evans, A., Fox, P., Lancaster, J., Zilles, K., et al. (2001). A probabilistic atlas and reference system for the human brain: international consortium for brain mapping (ICBM). Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci. 356, 1293–1322. doi: 10.1098/rstb.2001.0915
Sherif, T., Rioux, P., Rousseau, M.-E., Kassis, N., Beck, N., Adalat, R., et al. (2014). CBRAIN: a web-based, distributed computing platform for collaborative neuroimaging research. Front. Neuroinform. 8:54. doi: 10.3389/fninf.2014.00054
Vincent, R. D., Janke, A., Sled, J. G., Baghdadi, L., Neelin, P., and Evans, A. C. (2004). “MINC 2.0: a modality independent format for multidimensional medical images,” in 10th Annual Meeting of the Organization for Human Brain Mapping (Budapest).
Keywords: visualization, neuroimaging, neurology, WebGL, HTML5
Citation: Sherif T, Kassis N, Rousseau M-É, Adalat R and Evans AC (2015) BrainBrowser: distributed, web-based neurological data visualization. Front. Neuroinform. 8:89. doi: 10.3389/fninf.2014.00089
Received: 08 October 2014; Accepted: 17 December 2014;
Published online: 13 January 2015.
Edited by:John Van Horn, University of California at Los Angeles, USA
Reviewed by:Graham J. Galloway, The University of Queensland, Australia
Hidetoshi Ikeno, University of Hyogo, Japan
Copyright © 2015 Sherif, Kassis, Rousseau, Adalat and Evans. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Alan C. Evans, McGill Centre for Integrative Neuroscience, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, 3801 University Street, Webster 2B #208, Montreal, QC, H3A 2B4, Canada e-mail: email@example.com