Review ARTICLE

Front. Neurosci., 28 June 2010 | doi: 10.3389/fnins.2010.00049

Intracellular and extracellular tau

  • 1 Centro de Biología Molecular “Severo Ochoa”, Campus Cantoblanco, Universidad Autónoma de Madrid, Madrid, Spain
  • 2 Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Universidad Complutense, Madrid, Spain

In this short review is described the toxicity of modified intracellular tau and that of extracellular tau that could be released into the extracellular space after neuron death.

Keywords: tau, toxicity, Alzheimer disease, tauopathies

Citation: Avila J (2010) Intracellular and extracellular tau. Front. Neurosci. 4:49. doi: 10.3389/fnins.2010.00049

Received: 08 April 2010; Paper pending published: 26 April 2010;
Accepted: 09 June 2010; Published online: 28 June 2010

Edited by:

Emmanuel Planel, Centre Hospitalier de l’université Laval, Canada
Columbia University Medical Center, USA

Reviewed by:

Sebastien S. Hebert, Université Laval, Canada
Nicole Leclerc, Université de Montréal, Québec, Canada
Emmanuel Planel, Columbia University Medical Center, USA; Centre Hospitalier de l’université Laval, Canada

Copyright: © 2010 Avila. This is an open-access article subject to an exclusive license agreement between the authors and the Frontiers Research Foundation, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are credited.

*Correspondence: Jesús Avila, Centro de Biología Molecular “Severo Ochoa”, Campus Cantoblanco, Universidad Autónoma de Madrid, Nicolás Cabrera, 3, 28050 Madrid, Spain. e-mail: javila@cbm.uam.es

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