Original Research ARTICLE
Adaptogens stimulate neuropeptide Y and Hsp72 expression and release in neuroglia cells
- 1 Department of Research and Development, Swedish Herbal Institute Research and Development, Åskloster, Sweden
- 2 Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic, The Texas A&M Health Science Center College of Medicine, Temple, TX, USA
The beneficial stress–protective effect of adaptogens is related to the regulation of homeostasis via mechanisms of action associated with the hypothalamic–pituitary–adrenal axis and the regulation of key mediators of the stress response, such as molecular chaperones, stress-activated c-Jun N-terminal protein kinase, forkhead box O transcription factor, cortisol, and nitric oxide (NO). However, it still remains unclear what the primary upstream targets are in response to stimulation by adaptogens. The present study addresses this gap in our knowledge and suggests that an important target for adaptogen mediated stress–protective effector functions is the stress hormone neuropeptide Y (NPY). We demonstrated that ADAPT-232, a fixed combination of adaptogens Eleutherococcus senticosus root extract, Schisandra chinensis berry extract, Rhodiola rosea root extract SHR-5, and its active constituent salidroside, stimulated the expression of NPY and 72 kDa heat shock protein (Hsp72) in isolated human neuroglia cells. The central role of NPY was validated in experiments in which pre-treatment of human neuroglia cells with NPY-siRNA and HSF1-siRNA resulted in the significant suppression of ADAPT-232-induced NPY and Hsp72 release. Taken together our studies suggest that the stimulation and release of the stress hormones, NPY and Hsp72, into systemic circulation is an innate defense response against mild stressors (ADAPT-232), which increase tolerance and adaptation to stress.
Keywords: ADAPT-232, adaptogen, Eleutherococcus senticosus, heat shock proteins, neuropeptide Y, salidroside, Schisandra chinensis, Rhodiola rosea
Citation: Panossian A, Wikman G, Kaur P and Asea A (2012) Adaptogens stimulate neuropeptide Y and Hsp72 expression and release in neuroglia cells. Front. Neurosci. 6:6. doi: 10.3389/fnins.2012.00006
Received: 21 October 2011; Paper pending published: 12 November 2011;
Accepted: 13 January 2012; Published online: 01 February 2012.
Edited by:Maria M. Malagon, University of Cordoba, Spain
Reviewed by:James A. Carr, Texas Tech University, USA
Charlier Dominique Thierry, University of Liege, Belgium
Copyright: © 2012 Panossian, Wikman, Kaur and Asea. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.
*Correspondence: Alexander Panossian, Department of Research and Development, Swedish Herbal Institute Research and Development, Spårvägen 2, SE-432 96 Åskloster, Sweden. e-mail: firstname.lastname@example.org; Alexzander Asea, Division of Investigative Pathology, Scott & White Memorial Hospital and Clinic, The Texas A&M Health Science Center College of Medicine, 1901 South 1st Street, Temple, TX 76504, USA. e-mail: email@example.com