%A Ã…kerblom,Malin %A Sachdeva,Rohit %A Jakobsson,Johan %D 2012 %J Frontiers in Neuroscience %C %F %G English %K Let-7,microRNA,mir-124,miR-9,Neural Stem Cells,Neurogenesis %Q %R 10.3389/fnins.2012.00014 %W %L %M %P %7 %8 2012-February-07 %9 Review %+ Dr Johan Jakobsson,Lund University,Experimental Medical Sciences,BMC A11,LUND,Sweden,johan.jakobsson@med.lu.se %# %! microRNAs in neural stem cells %* %< %T Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives %U https://www.frontiersin.org/articles/10.3389/fnins.2012.00014 %V 6 %0 JOURNAL ARTICLE %@ 1662-453X %X In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.