Focused Review ARTICLE

Front. Neurosci., 30 November 2012 |

Linking adult olfactory neurogenesis to social behavior

  • Vision to Action Lab, Champalimaud Neuroscience Programme, Lisbon, Portugal

In the adult brain, new neurons are added to two brain areas: the olfactory bulb (OB) and the hippocampus. Newly-generated neurons integrate into the preexisting circuits, bringing a set of unique properties, such as increased plasticity and responsiveness to stimuli. However, the functional implications of the constant addition of these neurons remain unclear, although they are believed to be important for learning and memory. The levels of neurogenesis are regulated by a variety of environmental factors, as well as during learning, suggesting that new neurons could be important for coping with changing environmental demands. Notably, neurogenesis has been shown to be physiologically regulated in relation to reproductive behavior: neurogenesis increases in female mice upon exposure to cues of the mating partners, during pregnancy and lactation, and in male mice upon exposure to their offspring. In this scenario, and because of the key contribution of olfaction to maternal behavior, we sought to investigate the contribution of adult-generated neurons in the olfactory system to maternal behavior and offspring recognition. To do so, we selectively disrupted neurogenesis in the olfactory pathway of female mice using focal irradiation. Disruption of adult neurogenesis in the OB did not affect maternal behavior, or the ability of female mice to discriminate familiar from unfamiliar pups. However, reduction of olfactory neurogenesis resulted in abnormal social interaction of female mice, specifically with male conspecifics. Because the olfactory system is crucial for sex recognition, we suggest that the abnormal interaction with males could result from the inability to detect or discriminate male-specific odors and could therefore have implications for the recognition of potential mating partners. Here, I review the results of our study and others, and discuss their implications for our understanding of the function of adult neurogenesis.

Keywords: olfactory neurogenesis, maternal behavior, sex discrimination, social behavior, irradiation

Citation: Feierstein CE (2012) Linking adult olfactory neurogenesis to social behavior. Front. Neurosci. 6:173. doi: 10.3389/fnins.2012.00173

Received: 24 August 2012; Accepted: 15 November 2012;
Published online: 30 November 2012.

Edited by:

Serge Laroche, CNRS and University Paris-Sud, France

Reviewed by:

Heather A. Cameron, National Institutes of Health, USA
Paolo Peretto, Università degli Studidi Torino, Italy

Copyright © 2012 Feierstein. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.