%A Kim,Yun Tai %A Hur,Eun-Mi %A Snider,William %A Zhou,Feng-Quan %D 2011 %J Frontiers in Molecular Neuroscience %C %F %G English %K Axon branching,axon growth,Cytoskeleton,Growth cone,GSK3,microtubule plus end binding proteins,Microtubules,Neuronal polarization %Q %R 10.3389/fnmol.2011.00048 %W %L %M %P %7 %8 2011-November-23 %9 Review %+ Dr Feng-Quan Zhou,Johns Hopkins University,Department of Orthopaedic Surgery,215 Ross Research Building,720 Rutland Avenue,Baltimore,21287,MD,United States,fzhou4@zju.edu.cn %+ Dr Feng-Quan Zhou,Johns Hopkins University,The Solomon H. Snyder Department of Neuroscience,Baltimore,21287,MD,United States,fzhou4@zju.edu.cn %# %! GSK3 and neuronal morphogenesis %* %< %T Role of GSK3 Signaling in Neuronal Morphogenesis %U https://www.frontiersin.org/articles/10.3389/fnmol.2011.00048 %V 4 %0 JOURNAL ARTICLE %@ 1662-5099 %X Glycogen synthase kinase 3 (GSK3) is emerging as a key regulator of several aspects of neuronal morphogenesis including neuronal polarization, axon growth, and axon branching. Multiple signaling pathways have been identified that control neuronal polarization, including PI3K, Rho-GTPases, Par3/6, TSC–mTOR, and PKA–LKB1. However, how these pathways are coordinated is not clear. As GSK3 signaling exhibits crosstalk with each of these pathways it has the potential to integrate these polarity signals in the control neuronal polarization. After neurons establish polarity, GSK3 acts as an important signaling mediator in the regulation of axon extension and axon branching by transducing upstream signaling to reorganization of the axonal cytoskeleton, especially microtubules. Here we review the roles of GSK3 signaling in neuronal morphogenesis and discuss the underlying molecular mechanisms.