%A Larsen,Rylan %A Rao,Deepti %A Manis,Paul %A Philpot,Benjamin %D 2010 %J Frontiers in Synaptic Neuroscience %C %F %G English %K Auditory Cortex,endocannabinoid,Neuromodulation,presynaptic NMDA receptor,Somatosensory Cortex,Spike timing-dependent plasticity,Visual Cortex %Q %R 10.3389/fnsyn.2010.00009 %W %L %M %P %7 %8 2010-June-09 %9 Review %+ Paul Manis,The University of North Carolina at Chapel Hill,Curriculum in Neurobiology,Chapel Hill,United States,pmanis@med.unc.edu %+ Paul Manis,The University of North Carolina at Chapel Hill,Department of Cell and Molecular Physiology,Chapel Hill,United States,pmanis@med.unc.edu %+ Paul Manis,The University of North Carolina at Chapel Hill,Department of Otolaryngology/Head and Neck Surgery,Chapel Hill,United States,pmanis@med.unc.edu %+ Paul Manis,The University of North Carolina at Chapel Hill,UNC Neuroscience Center,Chapel Hill,United States,pmanis@med.unc.edu %# %! STDP in Developing Sensory Neocortex %* %< %T STDP in the developing sensory neocortex %U https://www.frontiersin.org/articles/10.3389/fnsyn.2010.00009 %V 2 %0 JOURNAL ARTICLE %@ 1663-3563 %X Spike timing-dependent plasticity (STDP) has been proposed as a mechanism for optimizing the tuning of neurons to sensory inputs, a process that underlies the formation of receptive field properties and associative memories. The properties of STDP must adjust during development to enable neurons to optimally tune their selectivity for environmental stimuli, but these changes are poorly understood. Here we review the properties of STDP and how these may change during development in primary sensory cortical layers 2/3 and 4, initial sites for intracortical processing. We provide a primer discussing postnatal developmental changes in synaptic proteins and neuromodulators that are thought to influence STDP induction and expression. We propose that STDP is shaped by, but also modifies, synapses to produce refinements in neuronal responses to sensory inputs.