This article is part of the Research Topic New Concepts in Brain Networks

Original Research ARTICLE

Front. Syst. Neurosci., 06 March 2012 | http://dx.doi.org/10.3389/fnsys.2012.00007

Prediction of task-related BOLD fMRI with amplitude signatures of resting-state fMRI

Sridhar S. Kannurpatti1, Bart Rypma2 and Bharat B. Biswal1*
  • 1 Department of Radiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
  • 2 School of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, TX, USA

Blood oxygen contrast-functional magnetic resonance imaging (fMRI) signals are a convolution of neural and vascular components. Several studies indicate that task-related (T-fMRI) or resting-state (R-fMRI) responses linearly relate to hypercapnic task responses. Based on the linearity of R-fMRI and T-fMRI with hypercapnia demonstrated by different groups using different study designs, we hypothesized that R-fMRI and T-fMRI signals are governed by a common physiological mechanism and that resting-state fluctuation of amplitude (RSFA) should be linearly related to T-fMRI responses. We tested this prediction in a group of healthy younger humans where R-fMRI, T-fMRI, and hypercapnic (breath hold, BH) task measures were obtained form the same scan session during resting state and during performance of motor and BH tasks. Within individual subjects, significant linear correlations were observed between motor and BH task responses across voxels. When averaged over the whole brain, the subject-wise correlation between the motor and BH tasks showed a similar linear relationship within the group. Likewise, a significant linear correlation was observed between motor-task activity and RSFA across voxels and subjects. The linear rest–task (R–T) relationship between motor activity and RSFA suggested that R-fMRI and T-fMRI responses are governed by similar physiological mechanisms. A practical use of the R–T relationship is its potential to estimate T-fMRI responses in special populations unable to perform tasks during fMRI scanning. Using the R–T relationship determined from the first group of 12 healthy subjects, we predicted the T-fMRI responses in a second group of 7 healthy subjects. RSFA in both the lower and higher frequency ranges robustly predicted the magnitude of T-fMRI responses at the subject and voxel levels. We propose that T-fMRI responses are reliably predictable to the voxel level in situations where only R-fMRI measures are possible, and may be useful for assessing neural activity in task non-compliant clinical populations.

Keywords: breath hold, resting-state fluctuations, BOLD, fMRI, hypercapnia, motor cortex, prediction, vascular

Citation: Kannurpatti SS, Rypma B and Biswal BB (2012) Prediction of task-related BOLD fMRI with amplitude signatures of resting-state fMRI. Front. Syst. Neurosci. 6:7. doi: 10.3389/fnsys.2012.00007

Received: 07 November 2011; Paper pending published: 04 December 2011;
Accepted: 04 February 2012; Published online: 06 March 2012.

Edited by:

Robert Turner, Max Planck Institute for Human Cognitive and Brain Sciences, Germany

Reviewed by:

Stefano Panzeri, Italian Institute of Technology, Italy
Fahmeed Hyder, Yale University, USA

Copyright: © 2012 Kannurpatti, Rypma and Biswal. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

*Correspondence: Bharat B. Biswal, Department of Radiology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, ADMC Building 5, Suite 575, 30 Bergen Street, Newark, NJ 07103, USA. e-mail: bbiswal@yahoo.com